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Case Reports
. 2022 Jul 13:27:101661.
doi: 10.1016/j.ajoc.2022.101661. eCollection 2022 Sep.

Raloxifene induced keratopathy: A case report

Ji Min Park  1 , Kyeong Do Jeong  2 , Min-Ji Kang  1 , Jee Hye Lee  1 , Jae Suk Kim  1 , Je Hyung Hwang  1
Affiliations
Case Reports

Raloxifene induced keratopathy: A case report

Ji Min Park et al. Am J Ophthalmol Case Rep. .

Abstract

Purpose: We report a case of corneal verticillata in a patient who had been taking raloxifene for a prolonged period. To our knowledge, this is the first case report of an ocular side effect of raloxifene.

Observations: A 69-year-old female patient presented to our clinic for her routine eye check-up. On slit-lamp examination, whorl-like subepithelial deposits were observed in the bilateral corneas. She was diagnosed with corneal verticillata (vortex keratopathy) caused by raloxifene. A follow-up evaluation was conducted after discontinuation of the drug; however, the corneal opacity did not improve.

Conclusions and importance: Patients with corneal verticillata should be asked regarding any intake of raloxifene for osteoporosis, as it may cause corneal verticillata.

Keywords: Drug-induced keratopathy; Keratopathy; Raloxifene; Selective estrogen receptor modulator.

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Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
Initial anterior segment photographs Anterior segment photographs at the patient's first visit are shown. Bilateral whorl-like subepithelial deposits are observed. (A: right eye, B: left eye).
Fig. 2
Fig. 2
Anterior segment photographs on follow-up The patient's anterior segment photographs 3 months later. No significant changes are observed. (A: right eye, B: left eye).
See this image and copyright information in PMC

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