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. 2022 Jun 1;23(1):3-13.
doi: 10.1080/19585969.2022.2043128. eCollection 2021.

Graph theory in paediatric epilepsy: A systematic review

Raffaele Falsaperla  1   2 , Giovanna Vitaliti  3 , Simona Domenica Marino  2 , Andrea Domenico Praticò  4 , Janette Mailo  5 , Michela Spatuzza  6 , Maria Roberta Cilio  7 , Rosario Foti  8 , Martino Ruggieri  4
Affiliations

Graph theory in paediatric epilepsy: A systematic review

Raffaele Falsaperla et al. Dialogues Clin Neurosci. .

Abstract

Graph theoretical studies have been designed to investigate network topologies during life. Network science and graph theory methods may contribute to a better understanding of brain function, both normal and abnormal, throughout developmental stages. The degree to which childhood epilepsies exert a significant effect on brain network organisation and cognition remains unclear. The hypothesis suggests that the formation of abnormal networks associated with epileptogenesis early in life causes a disruption in normal brain network development and cognition, reflecting abnormalities in later life. Neurological diseases with onset during critical stages of brain maturation, including childhood epilepsy, may threaten this orderly neurodevelopmental process. According to the hypothesis that the formation of abnormal networks associated with epileptogenesis in early life causes a disruption in normal brain network development, it is then mandatory to perform a proper examination of children with new-onset epilepsy early in the disease course and a deep study of their brain network organisation over time. In regards, graph theoretical analysis could add more information. In order to facilitate further development of graph theory in childhood, we performed a systematic review to describe its application in functional dynamic connectivity using electroencephalographic (EEG) analysis, focussing on paediatric epilepsy.

Keywords: Graph theory; brain network; childhood; paediatric epilepsy.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
Flowchart of the literature search process.
Figure 2.
Figure 2.
Visual example of the connectome in healthy brain (A) vs epileptic brain (B).
See this image and copyright information in PMC

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References

    1. Adebimpe A, Aarabi A, Bourel-Ponchel E, Mahmoudzadeh M, Wallois F.. 2015. Functional brain dysfunction in patients with benign childhood epilepsy as revealed by graph theory. PLoS One. 10(10):e0139228. - PMC - PubMed
    1. Berman R, Negishi M, Vestal M, Spann M, Chung MH, Bai X, Purcaro M, Motelow JE, Danielson N, Dix-Cooper L, et al. . 2010. Simultaneous EEG, fMRI, and behavior in typical childhood absence seizures. Epilepsia. 51(10):2011–2022. - PMC - PubMed
    1. Boersma M, Smit DJA, de Bie HMA, Van Baal GCM, Boomsma DI, de Geus EJC, Delemarre-van de Waal HA, Stam CJ.. 2011. Network analysis of resting state EEG in the developing young brain: structure comes with maturation. Hum Brain Mapp. 32(3):413–425. - PMC - PubMed
    1. Bomela W, Wang S, Chou CA, Li JS.. 2020. Real-time inference and detection of disruptive EEG networks for epileptic seizures. Sci Rep. 10(1):8653. - PMC - PubMed
    1. Bullmore E, Sporns O.. 2009. Complex brain networks: graph theoretical analysis of structural and functional systems. Nat Rev Neurosci. 10(3):186–198. - PubMed

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