Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 11:2022:5927384.
doi: 10.1155/2022/5927384. eCollection 2022.

Animal Models and Pathogenesis of Ulcerative Colitis

Xin Gao  1 , Jia Li  1 , Xueping Pang  1 , Kaiyuan Cong  1 , Chunlei Jiang  1 , Bingxuan Han  1 , Jiawei Gao  1 , Zhihao Wang  1 , Jiangshan Hu  1 , Kaijun Wen  1 , Xinfa Ye  1 , Liwen Dou  1
Affiliations

Animal Models and Pathogenesis of Ulcerative Colitis

Xin Gao et al. Comput Math Methods Med. .

Retraction in

Abstract

Background: Ulcerative colitis (UC) is a kind of inflammatory bowel disease which is needed to be predicted.

Objective: To analyze various animal models of UC conditions and summarizes the animal selection, model progression, and pathogenic mechanisms of UC animal models.

Methods: We surveyed the research papers published in PubMed, Google Scholar, Baidu Scholar, CNKI, SciFinder, and Web of Science in the past 5 years and discussed the experimental animals, modeling methods, and pathogenic mechanisms.

Results: In the selection of experimental animals, rats are considered the best experimental animals. The mainstream modeling methods can be categorized into the chemical stimulation method, immune stimulation method, and compound method, among which the compound method is the most successful. In the study of the pathogenesis of UC, the pathogenesis of UC is due to various pathogenic factors, such as nitric oxide (NO), prostaglandins (PG), proinflammatory factors (IL, TNF-α), and intestinal flora.

Conclusion: The method of building an animal model of UC is well-established, providing a more targeted selection of animal models for future related experiments.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Evolution of UC modeling methods in the last 30 years.
Figure 2
Figure 2
Chemical structure of DNCB.
Figure 3
Figure 3
Chemical structure of TNBS.
Figure 4
Figure 4
Chemical structure of DMH.
Figure 5
Figure 5
Chemical structure of DSS.
Figure 6
Figure 6
Mechanism of NO and PGE2 synergistic action to induce UC.
Figure 7
Figure 7
Chemical structure of PGE2.
Figure 8
Figure 8
Chemical structure of AA.
Figure 9
Figure 9
Mechanism of the interleukin factor stimulation of T cells to induce UC.
Figure 10
Figure 10
Mechanism of UC induction facilitated by intestinal flora through DAF recognition by DAEC.
See this image and copyright information in PMC

References

    1. Stephen O., Sain M., Maduh U. J., Jeong D. U. An efficient deep learning approach to pneumonia classification in healthcare. Journal of healthcare engineering . 2019;2019:7. doi: 10.1155/2019/4180949. - DOI - PMC - PubMed
    1. Kotze P. G., Steinwurz F., Francisconi C., et al. Review of the epidemiology and burden of ulcerative colitis in Latin America. Therapeutic Advances in Gastroenterology . 2020;13 doi: 10.1177/1756284820931739. - DOI - PMC - PubMed
    1. Low D., Nguyen D. D., Mizoguchi E. Animal models of ulcerative colitis and their application in drug research. Drug Design, Development and Therapy . 2013;12(7):1341–1357. doi: 10.2147/DDDT.S40107. - DOI - PMC - PubMed
    1. Jung E. C., Maibach H. I. Animal models for percutaneous absorption. Journal of Applied Toxicology . 2015;35(1):1–10. doi: 10.1002/jat.3004. - DOI - PubMed
    1. Chen Z. S., Zhang Z. Q., Nie Z. W. Duplication of animal model of ulcerative colitis and studies on rehabilitation effect of jianpiling prescription. Chinese Journal of Integrated Traditional and Western Medicine . 1990;10(8):488–490. - PubMed

Publication types

Substances