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. 2022 Jun 28:13:905619.
doi: 10.3389/fgene.2022.905619. eCollection 2022.

Association of Single-Nucleotide Polymorphisms of rs2383206, rs2383207, and rs10757278 With Stroke Risk in the Chinese Population: A Meta-analysis

Xuemei Hu  1   2 , Dongsen Wang  1   2 , Chunying Cui  2 , Qingjian Wu  2
Affiliations

Association of Single-Nucleotide Polymorphisms of rs2383206, rs2383207, and rs10757278 With Stroke Risk in the Chinese Population: A Meta-analysis

Xuemei Hu et al. Front Genet. .

Erratum in

Abstract

Several studies have reported that chromosome 9p21 is significantly associated with ischemic stroke (IS) risk, with the G allele associated with increased risk. However, controversial results have been reported in the literature. We systematically assessed the relationship between stroke and three 9p21 loci (rs2303206, rs2383207, and rs10757278) in this meta-analysis. First, we searched the PubMed and Embase databases for relevant studies. We then calculated odds ratios using the chi-squared test. The evaluation of experimental data was performed using bias tests and sensitivity analyses. We analyzed data from 16 studies involving 18,584 individuals of Chinese ancestry, including 14,033 cases and 14,656 controls. Our results indicated that chromosome 9p21 is significantly associated with IS (odds ratio: 1.15, 95% confidence interval: 1.1-1.20, p < 0.0001). Because the three single-nucleotide polymorphisms (rs2383206, rs2383207, and 10757278) have a linkage disequilibrium relationship, all three may increase the risk of IS.

Keywords: Chinese; chromosome 9p21; ischemic stroke; rs10757278; rs2383206; rs2383207.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flow chart of study selection in this meta-analysis.
FIGURE 2
FIGURE 2
Random-effects meta-analysis of the association between the three single-nucleotide polymorphisms (SNPs; rs2383207, rs2383206, and rs10757278) and ischemic stroke (IS). CI, confidence interval; OR, odds ratios.
FIGURE 3
FIGURE 3
Funnel plots corresponding to the random-effects meta-analysis of all studies of the three single-nucleotide polymorphisms (SNPs; rs2383207, rs2383206, and rs10757278) and ischemic stroke (IS).
FIGURE 4
FIGURE 4
Fixed effects meta-analysis of the association between the three single-nucleotide polymorphisms (SNPs; rs2383207, rs2383206, and rs10757278) and ischemic stroke (IS) in the second analysis. CI, confidence interval; OR, odds ratios.
FIGURE 5
FIGURE 5
Funnel plots corresponding to the fixed-effects meta-analysis of the three single-nucleotide polymorphisms (SNPs; rs2383207, rs2383206, and rs10757278) and ischemic stroke (IS) in the second analysis.
FIGURE 6
FIGURE 6
Fixed-effects meta-analysis of the associated between the three single-nucleotide polymorphisms (SNPs; rs2383207, rs2383206, and rs10757278) and ischemic stroke (IS) in the third analysis. CI, confidence interval; OR, odds ratios.
FIGURE 7
FIGURE 7
Funnel plots corresponding to the fixed-effects meta-analysis of the three single-nucleotide polymorphisms (SNPs; rs2383207, rs2383206, and rs10757278) and ischemic stroke (IS) in the third analysis.
See this image and copyright information in PMC

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References

    1. Akinyemi R., Arnett D. K., Tiwari H. K., Ovbiagele B., Sarfo F., Srinivasasainagendra V., et al. (2017). Interleukin-6 (IL-6) rs1800796 and Cyclin Dependent Kinase Inhibitor (CDKN2A/CDKN2B) rs2383207 are Associated with Ischemic Stroke in Indigenous West African Men. J. Neurological Sci. 379, 229–235. 10.1016/j.jns.2017.05.046 - DOI - PMC - PubMed
    1. Bi J., Yang L., Liu D., Wu J., Tong X., Cen S., et al. (2015). Sequence Variants on Chromosome 9p21 are Associated with Ischemic Stroke and the Lipids Level in Chinese Han Population. J. Stroke Cerebrovasc. Dis. 24, 894–900. 10.1016/j.jstrokecerebrovasdis.2014.12.020 - DOI - PubMed
    1. Chen J.-X., Liu J., Hu F., Bi Y., Li M., Zhao L. (2019). Genetic Variants on Chromosome 9p21 Confer Risks of Cerebral Infarction in the Chinese Population: A Meta-Analysis. Int. J. Immunopathol. Pharmacol. 33, 2058738419847852. 10.1177/2058738419847852 - DOI - PMC - PubMed
    1. Dehghan A., Bis J. C., White C. C., Smith A. V., Morrison A. C., Cupples L. A., et al. (2016). Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium. PLoS One 11, e0144997. 10.1371/journal.pone.0144997 - DOI - PMC - PubMed
    1. Dichgans M., Malik R., König I. R., Rosand J., Clarke R., Gretarsdottir S., et al. (2014). Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease: a Genome-Wide Analysis of Common Variants. Stroke 45, 24–36. 10.1161/strokeaha.113.002707 - DOI - PMC - PubMed

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