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. 2022 Jul 13:15:1343-1352.
doi: 10.2147/RMHP.S346300. eCollection 2022.

Assessment of Potentially Inappropriate Medications Using the EU (7)-PIM List, in a Sample of Portuguese Older Adults' Residents in Nursing Homes

Ana Isabel Plácido  1 , Ana Aguiar  1 , María Piñeiro-Lamas  2   3 , Fabiana Varallo  4 , Adolfo Figueiras  2   3   5 , Maria Teresa Herdeiro  6 , Fátima Roque  1   7
Affiliations

Assessment of Potentially Inappropriate Medications Using the EU (7)-PIM List, in a Sample of Portuguese Older Adults' Residents in Nursing Homes

Ana Isabel Plácido et al. Risk Manag Healthc Policy. .

Abstract

Abstract: Prescription of potentially inappropriate medication (PIM) in older adults is associated with poor clinical outcomes. The EU (7)-PIM list was created for the European market to improve pharmacotherapy in older adults.

Purpose: This work aims to characterize the medication profile and assess the presence of PIM, using the EU (7)-PIM list in older adults' residents at nursing homes.

Methods: Retrospective data were collected from the anonymized nursing home records. After PIM identification, a descriptive analysis was performed, and a generalized linear model for dependent negative binomial-type variables was constructed to assess the risk of PIM.

Results: Of the 210 participants (mean age 85.10), 82.40% were polymedicated. PIM was observed in 86.4% participants (mean per patient = 2.30± 0.10). The most common PIM were proton pump inhibitors (n = 121, 57.62%), followed by anxiolytics (n = 96, 45.71%). 64.30% of all patients take 2-4 PIM and 5.80% take five or more PIM. The occurrence of PIM is influenced by the number of prescribed medicines (RR 1.14; 95% CI 1.1.-1.17) and the presence of digestive system diseases (RR 1.05; 95% CI 1.0-1.09).

Conclusion: The high prevalence of PIM observations highlights the necessity of the implementation of guidelines to prevent PIM.

Keywords: elderly; institutionalized older adults; medication profile; prescription.

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Conflict of interest statement

The authors report no conflicts of interest in this work. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Figures

Figure 1
Figure 1
Most frequent pharmacological subgroups (third level), according to the ATC classification system of prescribed.
Figure 2
Figure 2
Directed acyclic graphs. Proposed relationship between the different variables (A) and the relationship between the different variables after the appropriate adjustment (B).
See this image and copyright information in PMC

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References

    1. World Population Ageing 2019 Highlights. World Population Ageing 2019 Highlights; 2019. doi:10.18356/9DF3CAED-EN - DOI
    1. da Costa FA, Silvestre L, Periquito C, et al. Drug-related problems identified in a sample of Portuguese institutionalised elderly patients and pharmacists’ interventions to improve safety and effectiveness of medicines. Drugs. 2016;3:1. doi:10.1007/s40801-016-0061-x - DOI - PMC - PubMed
    1. Plácido AI, Marante N, Morgado M, Herdeiro MT, Roque F. Intervenção farmacêutica na detecção de problemas relacionados com medicamentos em idosos institucionalizados: revisão sistemática [Pharmacists' interventions in medication-related problems in institutionalized elderly people: A systematic review]. Egitania Sci. 2020;2:25. Portuguese. doi:10.46691/es.v2i25.269 - DOI
    1. Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatr. 2017;17:1. doi:10.1186/s12877-017-0621-2 - DOI - PMC - PubMed
    1. Abdulah R, Insani WN, Destiani DP, Rohmaniasari N, Mohenathas ND, Barliana MI. Polypharmacy leads to increased prevalence of potentially inappropriate medication in the Indonesian geriatric population visiting primary care facilities. Ther Clin Risk Manag. 2018;14:1591–1597. doi:10.2147/TCRM.S170475 - DOI - PMC - PubMed