Ultra-rapid whole genome sequencing: A paradigm shift in the pre-transplant evaluation of neonatal acute liver failure

Affiliations

¹ Department of Pediatric and Adolescent Medicine , Mayo Clinic , Rochester , Minnesota , USA.
² Center for Individualized Medicine , Mayo Clinic , Rochester , Minnesota , USA.
³ Department of Clinical Genomics , Mayo Clinic , Rochester , Minnesota , USA.
⁴ Division of Neonatal-Perinatal Medicine , Mayo Clinic , Rochester , Minnesota , USA.
⁵ Rady Children's Institute for Genomic Medicine , San Diego , California , USA.
⁶ Pediatric Gastroenterology and Transplant Hepatology , Mayo Clinic , Rochester , Minnesota , USA.
⁷ Department of Pediatrics, Division of Gastroenterology , University of California San Diego , San Diego , California , USA.

Whitney S Thompson et al. Liver Transpl. 2023.

. 2023 Jan 1;29(1):118-121.

doi: 10.1002/lt.26547. Epub 2022 Aug 21.

¹ Department of Pediatric and Adolescent Medicine , Mayo Clinic , Rochester , Minnesota , USA.
² Center for Individualized Medicine , Mayo Clinic , Rochester , Minnesota , USA.
³ Department of Clinical Genomics , Mayo Clinic , Rochester , Minnesota , USA.
⁴ Division of Neonatal-Perinatal Medicine , Mayo Clinic , Rochester , Minnesota , USA.
⁵ Rady Children's Institute for Genomic Medicine , San Diego , California , USA.
⁶ Pediatric Gastroenterology and Transplant Hepatology , Mayo Clinic , Rochester , Minnesota , USA.
⁷ Department of Pediatrics, Division of Gastroenterology , University of California San Diego , San Diego , California , USA.

No abstract available

References

1. Taylor SA, Whitington PF. Neonatal acute liver failure. Liver Transpl. 2016;22:677–85.
1. Sundaram SS, Alonso EM, Narkewicz MR, Zhang S, Squires RH. Characterization and outcomes of young infants with acute liver failure. J Pediatr. 2011;159:813–8.e1.
1. Dimmock D, Caylor S, Waldman B, Benson W, Ashburner C, Carmichael JL, et al. Project baby bear: rapid precision care incorporating rWGS in 5 California children's hospitals demonstrates improved clinical outcomes and reduced costs of care. Am J Hum Genet. 2021;108:1231–8.
1. Greenmyer JR, Thompson WS, Mavis S, Hassan S, Weckwerth J, Hobbs C, et al. Neonatal familial hemophagocytic lymphohistiocytosis diagnosed with ultrarapid whole‐genome sequencing. Pediatr Blood Cancer. 2022;e29871. https://doi.org/10.1002/pbc.29871 - DOI
1. Farnaes L, Hildreth A, Sweeney NM, Clark MM, Chowdhury S, Nahas S, et al. Rapid whole‐genome sequencing decreases infant morbidity and cost of hospitalization. NPJ Genom Med. 2018;3:10.