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. 2022 Sep;37(9):1915-1923.
doi: 10.1002/mds.29159. Epub 2022 Jul 21.

18 F-Florzolotau Tau Positron Emission Tomography Imaging in Patients with Multiple System Atrophy-Parkinsonian Subtype

Feng-Tao Liu  1 , Xin-Yi Li  1 , Jia-Ying Lu  2 , Ping Wu  2 , Ling Li  2 , Xiao-Niu Liang  1   3 , Zi-Zhao Ju  2 , Fang-Yang Jiao  2 , Ming-Jia Chen  1 , Jing-Jie Ge  2 , Yi-Min Sun  1 , Jian-Jun Wu  1 , Tzu-Chen Yen  4 , Jian-Feng Luo  5 , Chuantao Zuo  2 , Jian Wang  1 ; Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI)
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18 F-Florzolotau Tau Positron Emission Tomography Imaging in Patients with Multiple System Atrophy-Parkinsonian Subtype

Feng-Tao Liu et al. Mov Disord. 2022 Sep.

Abstract

Background: Anecdotal evidence suggests that patients diagnosed with the parkinsonian subtype of multiple system atrophy (MSA-P) may show uptake of the second-generation tau positron emission tomography (PET) tracer 18 F-Florzolotau (previously known as 18 F-APN-1607) in the putamen.

Objectives: This study systematically investigated the localization and magnitude of 18 F-Florzolotau uptake in a relatively large cohort of patients with MSA-P.

Methods: 18 F-Florzolotau PET imaging was performed in 31 patients with MSA-P, 24 patients with Parkinson's disease (PD), and 20 age-matched healthy controls. 18 F-Florzolotau signal in the striatum was analyzed by visual inspection and classified as either positive or negative. Regional 18 F-Florzolotau binding was also expressed as standardized uptake value ratio (SUVR) to assess whether it was associated with core symptoms of MSA-P after adjustment for potential confounders.

Results: By visual inspection and semiquantitative SUVR comparisons, patients with MSA-P showed elevated 18 F-Florzolotau uptake in the putamen, globus pallidus, and dentate-a finding that was not observed in PD. This increased signal was significantly associated with the core symptoms of MSA-P. In addition, patients with MSA-P with cerebellar ataxia showed an elevated 18 F-Florzolotau uptake in the cerebellar dentate.

Conclusions: 18 F-Florzolotau tau PET imaging findings may reflect the clinical severity of MSA-P and can potentially discriminate between this condition and PD. © 2022 International Parkinson and Movement Disorder Society.

Keywords: 18F-Florzolotau; multiple system atrophy; positron emission tomography; tau; α-synucleinopathy.

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References

    1. Jabbari E, Holland N, Chelban V, et al. Diagnosis across the spectrum of progressive supranuclear palsy and corticobasal syndrome. JAMA Neurol 2020;77(3):377-387.
    1. Goedert M. Alpha-synuclein and neurodegenerative diseases. Nat Rev Neurosci 2001;2(7):492-501.
    1. Wenning GK, Colosimo C, Geser F, Poewe W. Multiple system atrophy. Lancet Neurol 2004;3(2):93-103.
    1. Outeiro TF, Koss DJ, Erskine D, et al. Dementia with lewy bodies: an update and outlook. Mol Neurodegener 2019;14(1):5
    1. Rosler TW, Tayaranian Marvian A, Brendel M, et al. Four-repeat tauopathies. Prog Neurobiol 2019;180:101644

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