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. 2022 Sep;35(9):e15727.
doi: 10.1111/dth.15727. Epub 2022 Jul 31.

Severe pemphigoid nodularis successfully treated with dupilumab

Affiliations

Severe pemphigoid nodularis successfully treated with dupilumab

Fatma Jendoubi et al. Dermatol Ther. 2022 Sep.
No abstract available

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Conflict of interest statement

Jendoubi Fatma has served as a consultant with honoraria for Sanofi Genzyme, Konstantinou Maria Polina and PAUL Carle have served as investigators for Sanofi Genzyme.

Figures

FIGURE 1
FIGURE 1
(A, B) Pruritic, erythematous, excoriated, papulonodular lesions of the abdomen, upper arms and thighs at initial presentation. (C) Complete response after 4 months of treatment with dupilumab. (D) Direct immunofluorescence showing a linear deposition of IgG and complement at the basement membrane zone. (E) Indirect immunofluorescence on salt‐split skin showing linear deposition of IgG antibodies localized on the blister roof.

References

    1. Powell AM, Albert S, Gratian MJ, Bittencourt J, Bhogal BS, Black MM. Pemphigoid nodularis (non‐bullous): a clinicopathological study of five cases. Br J Dermatol. 2002;147:343‐349. - PubMed
    1. Lamberts A, Meijer JM, Jonkman MF. Nonbullous pemphigoid: a systematic review. J Am Acad Dermatol. 2018;78:989‐995. - PubMed
    1. Teraki Y, Hotta T, Shiohara T. Skin‐homing interleukin‐4 and‐13‐producing cells contribute to bullous pemphigoid: remission of disease is associated with increased frequency of interleukin‐10‐producing cells. J Invest Dermatol. 2001;117:1097‐1102. - PubMed
    1. Takamura S, Teraki Y. Treatment of bullous pemphigoid with dupilumab: Dupilumab exerts its effect by primarily suppressing T‐helper 2 cytokines. J Dermatol. 2022. doi:10.1111/1346-8138.16428 - DOI - PubMed
    1. Abdat R, Waldman RA, de Bedout V, et al. Dupilumab as a novel therapy for bullous pemphigoid: a multicenter case series. J Am Acad Dermatol. 2020;83:46‐52. - PubMed

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