Diabetic lumbosacral plexopathy: an unpredictable clinical entity

Abstract

Purpose: Diabetic plexopathy is among the most unusual and disabling complication type 2 diabetic mellitus (T2DM) causing major suffering among affected individuals. The clinical presentation includes asymmetric muscle atrophy, weakness, and pain, typically associated with sudden weight loss. In part due to its rarity, this condition can be easily missed with serious consequences including potentially fatal complications.

Methods and results: A single case report of a 59-year-old woman with T2DM complicated by a lumbosacral plexopathy that presented with unusual clinical signs, symptoms and metabolic changes including (i) a life-threatening cardiac arrest due to a massive saddle pulmonary embolism (PE) secondary to a lower limb deep venous thrombosis ipsilateral to the plexopathy and (ii) an unexpected partial spontaneous remission of T2DM.

Conclusions: This case highlights the need for increased awareness and improved investigation and understanding of the pathogenesis and management of diabetic plexopathy, especially in rehabilitation settings for optimizing functional outcomes from rehabilitation input. Implications for rehabilitationDiabetic lumbosacral plexopathy (DLSP) is a distinct cause of neurological impairment requiring rehabilitation with a different natural history and prognosis. Its incidence almost three times higher than that of other common inflammatory neuropathies such as Guillain-Barré.Early recognition of DLSP in order to provide interventions, assessment, and therapeutic strategies in Rehabilitation.Diabetes plexopathy should remain an important consideration in the differential diagnoses when assessing any patient with diabetes presenting with acute pain and weakness in the extremities.

Keywords: Diabetic lumbosacral plexopathy; pulmonary embolism; rehabilitation; type 2 diabetes mellitus; unilateral lower leg weakness.