Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Jul 20;110(14):2201-2203.
doi: 10.1016/j.neuron.2022.05.027.

The role of hippocampal KCNQ2 channel in antidepressant actions of ketamine

Li Ma  1 , Kenji Hashimoto  2
Affiliations
Free article
Comment

The role of hippocampal KCNQ2 channel in antidepressant actions of ketamine

Li Ma et al. Neuron. .
Free article

Abstract

In this issue of Neuron, Lopez et al. report that KCNQ2 (potassium voltage-gated channel subfamily Q member 2) is essential for the sustained antidepressant-like effects of ketamine in glutamatergic neurons of the ventral hippocampus. This study implies that KCNQ2 activators can be novel antidepressants without the ketamine side effects.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests Dr. Hashimoto is the inventor of filed patent applications on “The use of R-ketamine in the treatment of psychiatric diseases,” “(S)-norketamine and salt thereof as pharmaceutical,” “R-ketamine and derivative thereof as prophylactic or therapeutic agent for neurodegeneration disease or recognition function disorder,” “Preventive or therapeutic agent and pharmaceutical composition for inflammatory diseases or bone diseases,” “R-ketamine and its derivatives as a preventive or therapeutic agent for a neurodevelopmental disorder,” and “TGF-β1 in the treatment of depression” by the Chiba University. Dr. Hashimoto has also received speakers’ honoraria, a consultant fee, or research support from Abbott Russia, Daiichi-Sankyo, Meiji Seika Pharma, Seikagaku Corporation, Dainippon-Sumitomo, Taisho, Otsuka, Murakami Farm, and Perception Neuroscience (New York, USA).

Comment on

  • Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.
    Lopez JP, Lücken MD, Brivio E, Karamihalev S, Kos A, De Donno C, Benjamin A, Yang H, Dick ALW, Stoffel R, Flachskamm C, Ressle A, Roeh S, Huettl RE, Parl A, Eggert C, Novak B, Yan Y, Yeoh K, Holzapfel M, Hauger B, Harbich D, Schmid B, Di Giaimo R, Turck CW, Schmidt MV, Deussing JM, Eder M, Dine J, Theis FJ, Chen A. Lopez JP, et al. Neuron. 2022 Jul 20;110(14):2283-2298.e9. doi: 10.1016/j.neuron.2022.05.001. Epub 2022 May 31. Neuron. 2022. PMID: 35649415

Publication types

MeSH terms

LinkOut - more resources