Core outcome set for peripheral regional anesthesia research: a systematic review and Delphi study

Jeremy Hill¹, Toby Ashken², Simeon West², Alan James Robert Macfarlane^{3

4}, Kariem El-Boghdadly⁵, Eric Albrecht⁶, Ki Jinn Chin⁷, Ben Fox⁸, Ashwani Gupta⁹, Stephen Haskins^{10

11}, Nat Haslam¹², Rosemary Margaret Gilmore Hogg¹³, Anil Hormis¹⁴, David F Johnston¹⁵, Edward R Mariano^{16

17}, Peter Merjavy¹⁸, Timothy Moll¹⁹, James Parry²⁰, Amit Pawa⁵, Kim Russon²¹, Maria Paz Sebastian²⁰, Lloyd Turbitt¹³, Jonathan Womack²², Maria Chazapis²

Affiliations

¹ Department of Anaesthetics, University College London Hospitals NHS Foundation Trust, London, UK jeremy.hill1@nhs.net.
² Department of Anaesthetics, University College London Hospitals NHS Foundation Trust, London, UK.
³ Glasgow Royal Infirmary, Glasgow, UK.
⁴ University of Glasgow, Glasgow, UK.
⁵ Anaesthesia, Guy's and St Thomas' NHS Foundation Trust, London, UK.
⁶ Department of Anaesthesia, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
⁷ Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada.
⁸ Department of Anaesthesia, Queen Elizabeth Hospital King's Lynn NHS Foundation Trust, King's Lynn, UK.
⁹ Anaesthetics, Gateshead Health NHS Foundation Trust, Gateshead, UK.
¹⁰ Department of Anesthesiology, Critical Care and Pain Management, Hospital for Special Surgery Department of Anesthesiology Critical Care & Pain Management, New York, New York, USA.
¹¹ Department of Anesthesiology, Weill Cornell Medical College, New York, New York, USA.
¹² City Hospitals Sunderland NHS Foundation Trust, South Shields, UK.
¹³ Department of Anaesthesia, Belfast Health and Social Care Trust, Belfast, UK.
¹⁴ Department of Anaesthetics, The Rotherham NHS Foundation Trust, UK, Rotherham NHS Foundation Trust, Rotherham, UK.
¹⁵ Belfast Health and Social Care Trust, Belfast, UK.
¹⁶ Anesthesiology and Perioperative Care Service, VA Palo Alto Health Care System, Palo Alto, California, USA.
¹⁷ Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.
¹⁸ Anaesthetic, Craigavon Area Hospital, Portadown, UK.
¹⁹ Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
²⁰ Royal National Orthopaedic Hospital NHS Trust, Stanmore, UK.
²¹ South Tyneside and Sunderland NHS Foundation Trust, South Shields, Tyne and Wear, UK.
²² Royal Victoria Infirmary, Newcastle upon Tyne, UK.

PMID: 35863787
DOI: 10.1136/rapm-2022-103751

Review

Core outcome set for peripheral regional anesthesia research: a systematic review and Delphi study

Jeremy Hill et al. Reg Anesth Pain Med. 2022.

. 2022 Jul 21:rapm-2022-103751.

doi: 10.1136/rapm-2022-103751. Online ahead of print.

Authors

Affiliations

¹ Department of Anaesthetics, University College London Hospitals NHS Foundation Trust, London, UK jeremy.hill1@nhs.net.
² Department of Anaesthetics, University College London Hospitals NHS Foundation Trust, London, UK.
³ Glasgow Royal Infirmary, Glasgow, UK.
⁴ University of Glasgow, Glasgow, UK.
⁵ Anaesthesia, Guy's and St Thomas' NHS Foundation Trust, London, UK.
⁶ Department of Anaesthesia, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
⁷ Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada.
⁸ Department of Anaesthesia, Queen Elizabeth Hospital King's Lynn NHS Foundation Trust, King's Lynn, UK.
⁹ Anaesthetics, Gateshead Health NHS Foundation Trust, Gateshead, UK.
¹⁰ Department of Anesthesiology, Critical Care and Pain Management, Hospital for Special Surgery Department of Anesthesiology Critical Care & Pain Management, New York, New York, USA.
¹¹ Department of Anesthesiology, Weill Cornell Medical College, New York, New York, USA.
¹² City Hospitals Sunderland NHS Foundation Trust, South Shields, UK.
¹³ Department of Anaesthesia, Belfast Health and Social Care Trust, Belfast, UK.
¹⁴ Department of Anaesthetics, The Rotherham NHS Foundation Trust, UK, Rotherham NHS Foundation Trust, Rotherham, UK.
¹⁵ Belfast Health and Social Care Trust, Belfast, UK.
¹⁶ Anesthesiology and Perioperative Care Service, VA Palo Alto Health Care System, Palo Alto, California, USA.
¹⁷ Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.
¹⁸ Anaesthetic, Craigavon Area Hospital, Portadown, UK.
¹⁹ Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
²⁰ Royal National Orthopaedic Hospital NHS Trust, Stanmore, UK.
²¹ South Tyneside and Sunderland NHS Foundation Trust, South Shields, Tyne and Wear, UK.
²² Royal Victoria Infirmary, Newcastle upon Tyne, UK.

PMID: 35863787
DOI: 10.1136/rapm-2022-103751

Abstract

Background/importance: There is heterogeneity among the outcomes used in regional anesthesia research.

Objective: We aimed to produce a core outcome set for regional anesthesia research.

Methods: We conducted a systematic review and Delphi study to develop this core outcome set. A systematic review of the literature from January 2015 to December 2019 was undertaken to generate a long list of potential outcomes to be included in the core outcome set. For each outcome found, the parameters such as the measurement scale, timing and definitions, were compiled. Regional anesthesia experts were then recruited to participate in a three-round electronic modified Delphi process with incremental thresholds to generate a core outcome set. Once the core outcomes were decided, a final Delphi survey and video conference vote was used to reach a consensus on the outcome parameters.

Results: Two hundred and six papers were generated following the systematic review, producing a long list of 224 unique outcomes. Twenty-one international regional anesthesia experts participated in the study. Ten core outcomes were selected after three Delphi survey rounds with 13 outcome parameters reaching consensus after a final Delphi survey and video conference.

Conclusions: We present the first core outcome set for regional anesthesia derived by international expert consensus. These are proposed not to limit the outcomes examined in future studies, but rather to serve as a minimum core set. If adopted, this may increase the relevance of outcomes being studied, reduce selective reporting bias and increase the availability and suitability of data for meta-analysis in this area.

Keywords: OUTCOMES; REGIONAL ANESTHESIA; analgesia.

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Conflict of interest statement

Competing interests: EA received grants from the Swiss Academy for Anaesthesia Research, Lausanne, Switzerland; B. Braun Medical AG, Sempach, Switzerland; and the Swiss National Science Foundation to support his clinical research. EA has also received an honorarium from B. Braun Medical AG Switzerland, Sintetica Ltd UK and MSD AG Switzerland. BF declares honoraria from B. Braun, Sintetica, Brain Therapeutics and Hospitality Medovate. ERM chairs the American Society of Anaesthesiologists Committee on Regional Anesthesia and Acute Pain Medicine. He is a former director of the American Society of Regional Anesthesia and Pain Medicine (ASRA). TA, AG, NH, DFJ, AJRM, AP, MPS, LT, SW, JW are members of the Board of Regional Anaesthesia UK (RA-UK). KE-B declares honoraria from GE Healthcare, Ambu, Fisher and Paykel, Edwards Lifesciences. AJRM declares honoraria and/or research funding from Intelligent Ultrasound. PM is a board member of European Diploma in Regional Anaesthesia (EDRA) and declares honoraria from B. Braun Medical and Medovate. AP declares honoraria from GE Healthcare, Butterfly Net, Sintetica UK and Pacira. KR was the President of the British Association of Day Surgery.

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Core outcome set for peripheral regional anesthesia research: a systematic review and Delphi study

Affiliations

Core outcome set for peripheral regional anesthesia research: a systematic review and Delphi study

Authors

Affiliations

Abstract

Conflict of interest statement

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LinkOut - more resources

Full Text Sources