Funding Support and Author Disclosures Prof Di Mario has received institutional research grants from AMGEN, Abbott Vascular, Behring, Boston Scientific, Chiesi Pharmaceuticals, Daiichi-Sankyo, Edwards Lifesciences, Medtronic, Shockwave Medical, and Volcano Philips; and he is member and president of the EuroCTO Club, which receives annual grants to support its congress and other activities from Abbott, Asahi Intecc, Biotronik, Boston Scientific, Braun, IMDS, OrbusNeich, Philips Volcano, Shockwave, SISMedical, Teleflex, and Terumo. Dr Ciardetti has reported that he has no relationships relevant to the contents of this paper to disclose.