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Review
. 2022 Jul 5:13:923152.
doi: 10.3389/fimmu.2022.923152. eCollection 2022.

Regenerative Role of T Cells in Nerve Repair and Functional Recovery

Xiaoxuan Tang  1   2 , Qiaoyuan Li  1 , Tingting Huang  1 , Han Zhang  2 , Xiaoli Chen  1 , Jue Ling  1 , Yumin Yang  1
Affiliations
Review

Regenerative Role of T Cells in Nerve Repair and Functional Recovery

Xiaoxuan Tang et al. Front Immunol. .

Abstract

The immune system is essential in the process of nerve repair after injury. Successful modulation of the immune response is regarded as an effective approach to improving treatment outcomes. T cells play an important role in the immune response of the nervous system, and their beneficial roles in promoting regeneration have been increasingly recognized. However, the diversity of T-cell subsets also delivers both neuroprotective and neurodegenerative functions. Therefore, this review mainly discusses the beneficial impact of T-cell subsets in the repair of both peripheral nervous system and central nervous system injuries and introduces studies on various therapies based on T-cell regulation. Further discoveries in T-cell mechanisms and multifunctional biomaterials will provide novel strategies for nerve regeneration.

Keywords: T cells; immune response; nerve injury; nerve regeneration; neuroinflammation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The neuroprotective and neurodestructive impacts of T-cell subsets in CNS/PNS nerve injury. Generally, Th2 cells and Treg cells produce anti-inflammatory cytokines such as IL-4 or IL-10 to promote nerve repair, whereas Th1 and Th17 cells produce IFN-γ or IL-17 to boost acute inflammatory responses.
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