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Case Reports
. 2022 Jul 18;10(7):e6020.
doi: 10.1002/ccr3.6020. eCollection 2022 Jul.

Presentation and treatment of aggressive, Triple-Negative carcinosarcoma of the breast

Niels Vizgan  1 , Tahereh Orouji Jokar  2 , Ladan Enayati  3 , Muhammad Salyana  3 , Vladimir K Gotlieb  3
Affiliations
Case Reports

Presentation and treatment of aggressive, Triple-Negative carcinosarcoma of the breast

Niels Vizgan et al. Clin Case Rep. .

Abstract

An extremely rare form of breast cancer, breast carcinosarcoma accounts for less than a percent of all breast malignancies and is highly aggressive. Composed of both cancerous epithelial and mesenchymal cell types, breast carcinosarcoma is associated with a poor prognosis compared to more common breast cancers, and typically lack the receptors typical of other breast carcinomas, which minimize potential targets for treatment. In this case report, we discuss a 56-year-old patient affected by carcinosarcoma of the breast at a T2N1 stage, and the decision-making process that factored into her treatment plan.

Keywords: hematology; metaplastic breast cancer; oncology; triple‐negative breast cancer.

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Conflict of interest statement

The authors have no conflict of interest to declare. No funding was provided for this submission.

Figures

FIGURE 1
FIGURE 1
(A) Ultrasonography of the patient's left breast shows an irregularly shaped, lobulated neoplasm of mixed echogenicity corresponding to the patient's palpable mass. (B) Chest X‐ray showing a circumscribed mass in the left breast
FIGURE 2
FIGURE 2
Metaplastic carcinoma: Left side shows cartilaginous component; right side adenocarcinoma; 4X (low magnification)
FIGURE 3
FIGURE 3
Poorly differentiated adenocarcinoma component at 40X (high magnification)
FIGURE 4
FIGURE 4
Chondroid component at 10X (medium magnification)
FIGURE 5
FIGURE 5
Chondroid component at 40X (high magnification)
See this image and copyright information in PMC

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