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. 2022 Jul 19;10(8):e01009.
doi: 10.1002/rcr2.1009. eCollection 2022 Aug.

Platypnea-orthodeoxia syndrome in a patient with ongoing COVID-19

Maki Asami-Noyama  1 , Misa Harada  1 , Yukari Hisamoto  1 , Taiga Kobayashi  2 , Keiji Oishi  1 , Nobutaka Edakuni  1 , Tsunahiko Hirano  1 , Tomoyuki Kakugawa  3 , Kazuto Matsunaga  1
Affiliations

Platypnea-orthodeoxia syndrome in a patient with ongoing COVID-19

Maki Asami-Noyama et al. Respirol Case Rep. .

Abstract

SARS-CoV-2 infection of the vascular endothelium causes excessive vasodilation. It is important in the rehabilitation of patients with COVID-19 to recognize that increased blood flow in lung lesions at the base of the lung due to vasodilation may cause V/Q mismatch and result in platypnea-orthodeoxia syndrome.

Keywords: COVID‐19; V/Q mismatch; perfusion scintigraphy; platypnea‐orthodeoxia syndrome.

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Conflict of interest statement

None declared.

Figures

FIGURE 1
FIGURE 1
A contrast CT scan revealed an obvious vascular enlargement toward the lesions in the lower lobe bilaterally (arrowhead). CT, computed tomography
FIGURE 2
FIGURE 2
(A, B) A ventilation/perfusion single‐photon emission computed tomography combined with computed tomography (V/Q SPECT/CT) showed perfusion uptake within and around the fibrotic lesions in the lower lobe bilaterally. CT, computed tomography
See this image and copyright information in PMC

References

    1. Lang M, Som A, Carey D, Reid N, Mendoza DP, Flores EJ, et al. Pulmonary vascular manifestations of COVID‐19 pneumonia. Radiol Cardiothorac Imaging. 2020;2:e200277. - PMC - PubMed

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