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Case Reports
. 2022 May 1;42(Sp. 1):17-25.
doi: 10.7705/biomedica.6319.

Healing of a chronic ulcer of the lower limb of venous origin with fresh human amniochorionic membrane allograft

[Article in English, Spanish]
Alberto Piamo  1 , Mayra García  2 , Dayset Romero  3 , Daisy Ferrer  4
Affiliations
Case Reports

Healing of a chronic ulcer of the lower limb of venous origin with fresh human amniochorionic membrane allograft

[Article in English, Spanish]
Alberto Piamo et al. Biomedica. .

Abstract
in English, Spanish

In its fresh state, the amniochorionic membrane contains various multipotential cells, growth factors, and extracellular matrix proteins that contribute to the healing of chronic vascular ulcers. To demonstrate its effectiveness, a fresh human placental membrane allograft was applied to a chronic venous ulcer in the lower limb of an 89-year-old female patient with a 12 x 10 cm ulcerated lesion of 40 years of evolution in the malleolar area of her left lower limb. Sixty days after the graft, the ulcer was healed in 100% of its surface and a light pink scar on the edges indicated possible pigmentation. Fresh human amniochorionic membrane allograft is a therapeutic alternative for the healing of refractory chronic vascular ulcers of the lower extremities.

En su estado fresco, la membrana amniocoriónica contiene varias células multipotenciales, factores de crecimiento y proteínas de la matriz extracelular que contribuyen a la cicatrización de las úlceras vasculares crónicas. Para demostrar su efectividad, se recurrió a un aloinjerto de membrana placentaria humana fresca para tratar una úlcera venosa crónica, de 12 x 10 cm y con 40 años de evolución, en el zona maleolar interna e izquierda de una paciente de 89 años de edad. Transcurridos 60 días del injerto, la úlcera se encontraba cicatrizada en el 100 % de su superficie, observándose una cicatriz rosada clara en cuyos bordes se apreciaron intentos de pigmentación. El aloinjerto de membrana amniocoriónica humana fresca es una alternativa terapéutica para la curación de úlceras vasculares crónicas persistentes en las extremidades inferiores.

Keywords: Varicose ulcer; allografts; amnion.

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Conflict of interest statement

Conflicto de intereses: Se declara que no existe ningún conflicto de intereses

Figures

Figura 1
Figura 1. Lesión ulcerada de 40 años de evolución en región maleolar izquierda
Figura 2
Figura 2. Proceso de disección de la membrana amniótica
Figura 3
Figura 3. Aplicación de membrana Implantación de la membrana amniocoriónica
Figura 4
Figura 4. Reabsorción de la membrana
Figura 5
Figura 5. Proceso de cicatrización en el décimo día
Figura 6
Figura 6. Día 30 de evolución: cicatrización del 50 % de la úlcera
Figura 7
Figura 7. Cicatrización del 100 % de toda la superficie de la úlcera
See this image and copyright information in PMC

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