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. 2022 Oct;47(10):3485-3493.
doi: 10.1007/s00261-022-03602-5. Epub 2022 Jul 22.

Pre- and post-therapeutic evaluation of liver and spleen in type I and type III Gaucher's disease using diffusion tensor imaging

Eman Alnaghy  1 , Ahmed Abdel Razek  2 , Ebrahim Abdelhalim  3
Affiliations

Pre- and post-therapeutic evaluation of liver and spleen in type I and type III Gaucher's disease using diffusion tensor imaging

Eman Alnaghy et al. Abdom Radiol (NY). 2022 Oct.

Abstract

Purpose: To assess the role of diffusion tensor imaging in assessing liver and splenic parenchymal infiltration in Gaucher's disease (G.D.) type I and III before and after therapy.

Methods: A prospective study was conducted upon 28 consecutive patients with G.D. type I and III and 28 age and sex-matched controls. They underwent an MRI and DTI of the liver and spleen. Mean diffusivity (M.D.) and fractional anisotropy (F.A.) values of the liver and spleen were evaluated before and after treatment and compared with control.

Results: There was a statistically significant difference in the M.D. value of the liver and spleen between untreated patients and controls and between control and treated patients and in the M.D. value of the liver and spleen between untreated and treated patients. There is a statistically significant difference in the F.A. value of the liver and spleen between untreated patients and controls and in the F.A. value of the liver and spleen between untreated and treated patients. Hemoglobin level was positively correlated with the M.D. value of the spleen. Clinical score was negatively correlated with M.D. value of the spleen and was positively correlated with F.A. values of the liver and F.A. values of the spleen. Spleen volume was negatively correlated with M.D. values of the spleen.

Conclusion: Significant difference in M.D. and F.A. values of liver and splenic parenchyma in p atients with type I and III G.D. and controls, and between untreated and treated patients. The M.D. and F.A. values were well correlated with some biomarkers of disease activity.

Keywords: Diffusion tensor imaging; Gaucher’s disease; Liver; M.R. imaging; Spleen.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Patients flow chart
Fig. 2
Fig. 2
Showing ROI sits on DTI images of liver and spleen in patient (a, b), and in control (c, d)
Fig. 3
Fig. 3
a Receiver operating characteristic (ROC) curve for M.D. values of the liver and spleen in untreated patients and control. b Receiver operating characteristic (ROC) curve for FA values of the liver and spleen in control and untreated patients
Fig. 4
Fig. 4
a ROC curve for M.D. values of the liver and spleen in untreated and treated patients. b ROC curve for F.A. values of the liver and spleen in untreated and treated patients
See this image and copyright information in PMC

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