Compton imaging for medical applications

Abstract

Compton imaging exploits inelastic scattering, known as Compton scattering, using a Compton camera consisting of a scatterer detector in the front layer and an absorber detector in the back layer. This method was developed for astronomy, and in recent years, research and development for environmental and medical applications has been actively conducted. Compton imaging can discriminate gamma rays over a wide energy range from several hundred keV to several MeV. Therefore, it is expected to be applied to the simultaneous imaging of multiple nuclides in nuclear medicine and prompt gamma ray imaging for range verification in particle therapy. In addition, multiple gamma coincidence imaging is expected to be realized, which allows the source position to be determined from a single coincidence event using nuclides that emit multiple gamma rays simultaneously, such as nuclides that emit a single gamma ray simultaneously with positron decay. This review introduces various efforts toward the practical application of Compton imaging in the medical field, including in vivo studies, and discusses its prospects.

Keywords: Compton imaging; Multi-isotope imaging; Multiple-gamma coincidence imaging; Nuclear medicine; Particle therapy; Targeted radiotherapy.