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Comment
. 2022 Jul 22;7(73):eabq6509.
doi: 10.1126/sciimmunol.abq6509. Epub 2022 Jul 22.

CXCL9 and CXCL10 bring the heat to tumors

Robin Reschke  1 , Thomas F Gajewski  1   2   3
Affiliations
Comment

CXCL9 and CXCL10 bring the heat to tumors

Robin Reschke et al. Sci Immunol. .

Abstract

CXCL9 and CXCL10 can be produced by antigen-presenting cells (dendritic cells or macrophages) and by tumor cells. Hoch et al. demonstrated that CXCL9 and CXCL10 co-localize with LAG3+ T cells expressing CCL4 or CXCL13 and contribute to the generation of a "hot" tumor microenvironment.

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