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Comment
. 2022 Jul 21;29(7):1065-1067.
doi: 10.1016/j.chembiol.2022.06.008.

Tag you're it: A phosphatase inhibitor changes the fate of intracellular mycobacteria

Charul Jani  1 , Amy K Barczak  2
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Tag you're it: A phosphatase inhibitor changes the fate of intracellular mycobacteria

Charul Jani et al. Cell Chem Biol. .
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Abstract

In this issue of Cell Chemical Biology, Berton and colleagues describe a small-molecule inhibitor of the metal-dependent phosphatase PPM1A that enhances phosphorylation of the autophagy adapter p62. Inhibiting PPM1A results in enhanced clearance of Mycobacterium tuberculosis-infected macrophages, pointing to phosphatases as potential targets for host-directed therapies for tuberculosis.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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