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Comment
. 2022 Aug 8;40(8):815-817.
doi: 10.1016/j.ccell.2022.06.013. Epub 2022 Jul 21.

The aging lung microenvironment awakens melanoma metastases

Brandon M Murphy  1 , Christin E Burd  2
Affiliations
Free article
Comment

The aging lung microenvironment awakens melanoma metastases

Brandon M Murphy et al. Cancer Cell. .
Free article

Abstract

In a recent publication in Nature, Fane et al. establish WNT5A as a central, age-sensitive regulator of the dormancy-to-reactivation axis of melanoma. They show that aged fibroblasts in the lungs suppress WNT5A signaling induced at the primary tumor site to awaken dormant melanoma cells and promote the outgrowth of metastases.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Stromal changes in the aged lung induce an emergence from melanoma dormancy.
    Fane ME, Chhabra Y, Alicea GM, Maranto DA, Douglass SM, Webster MR, Rebecca VW, Marino GE, Almeida F, Ecker BL, Zabransky DJ, Hüser L, Beer T, Tang HY, Kossenkov A, Herlyn M, Speicher DW, Xu W, Xu X, Jaffee EM, Aguirre-Ghiso JA, Weeraratna AT. Fane ME, et al. Nature. 2022 Jun;606(7913):396-405. doi: 10.1038/s41586-022-04774-2. Epub 2022 Jun 1. Nature. 2022. PMID: 35650435 Free PMC article.

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