Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Aug;38(3):605-620.
doi: 10.1016/j.cger.2022.03.006. Epub 2022 Mar 21.

COVID-19 Vaccines in Older Adults: Challenges in Vaccine Development and Policy Making

Chih-Kuang Liang  1 , Wei-Ju Lee  2 , Li-Ning Peng  3 , Lin-Chieh Meng  4 , Fei-Yuan Hsiao  5 , Liang-Kung Chen  6
Affiliations
Review

COVID-19 Vaccines in Older Adults: Challenges in Vaccine Development and Policy Making

Chih-Kuang Liang et al. Clin Geriatr Med. 2022 Aug.

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has had strong adverse impacts on vulnerable populations, such as frail older adults. The success of COVID-19 vaccine development, together with extensive global public health efforts, has brought hope to the control of the COVID-19 pandemic. Nevertheless, challenges in COVID-19 vaccine development and vaccination strategies among older people remain. This article reviews vaccinations in older adults, compares COVID-19 vaccine platforms, the efficacy and safety of COVID-19 vaccines in frail older people in long-term care settings, and the challenges of COVID-19 vaccine development and policy making for vaccination strategies in older adults.

Keywords: COVID-19; Disability; Frailty; Immunosenescence; Vaccine.

PubMed Disclaimer

References

    1. WHO coronavirus disease (COVID-19) dashboard. World Health Organization. https://covid19.who.int/ Available at. Accessed January 28, 2022.
    1. Mostaza J.M., García-Iglesias F., González-Alegre T., et al. Clinical course and prognostic factors of COVID-19 infection in an elderly hospitalized population. Arch Gerontol Geriatr. 2020;91:104204. - PMC - PubMed
    1. Rowe T.A., Patel M., O'Conor R., et al. COVID-19 exposures and infection control among home care agencies. Arch Gerontol Geriatr. 2020;91:104214. - PMC - PubMed
    1. Bernabeu-Wittel M., Ternero-Vega J.E., Díaz-Jiménez P., et al. Death risk stratification in elderly patients with covid-19. A comparative cohort study in nursing homes outbreaks. Arch Gerontol Geriatr. 2020;91:104240. - PMC - PubMed
    1. Pranata R., Huang I., Lim M.A., et al. Delirium and mortality in coronavirus disease 2019 (COVID-19) - a systematic review and meta-analysis. Arch Gerontol Geriatr. 2021;95:104388. - PMC - PubMed

Publication types