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. 2022 Aug;46(8):426-435.
doi: 10.1016/j.medine.2021.12.013.

Impact of Aspergillus spp. isolation in the first 24 hours of admission in critically ill patients with severe influenza virus pneumonia

L Claverias  1 , X Daniel  2 , I Martín-Loeches  3 , P Vidal-Cortez  4 , F Gómez-Bertomeu  5 , S Trefler  6 , R Zaragoza  7 , M Borges-Sa  8 , L F Reyes  9 , G Quindós  10 , J Peman  11 , M Bodí  12 , E Díaz  13 , C Sarvisé  5 , E Pico  5 , E Papiol  14 , J Solé-Violan  15 , J Marín-Corral  16 , J J Guardiola  17 , A Rodríguez  12 ; GETGAG/SEMICYUC Working Group
Affiliations

Impact of Aspergillus spp. isolation in the first 24 hours of admission in critically ill patients with severe influenza virus pneumonia

L Claverias et al. Med Intensiva (Engl Ed). 2022 Aug.

Abstract

Objective: To determine the incidence and impact of Aspergillus spp. isolation (AI) on ICU mortality in critically ill patients with severe influenza pneumonia during the first 24h of admission.

Design: Secondary analysis of an observational and prospective cohort study.

Setting: ICUs voluntary participating in the Spanish severe Influenza pneumonia registry, between June 2009 and June 2019.

Patients: Consecutive patients admitted to the ICU with diagnosis of severe influenza pneumonia, confirmed by real-time polymerase chain reaction.

Interventions: None.

Main variables of interest: Incidence of AI in respiratory samples. Demographic variables, comorbidities, need for mechanical ventilation and the presence of shock according at admission. Acute Physiology and Chronic Health Evaluation II (APACHE II) scale calculated on ICU admission.

Results: 3702 patients were analyzed in this study. AI incidence was 1.13% (n=42). Hematological malignancies (OR 4.39, 95% CI 1.92-10.04); HIV (OR 3.83, 95% CI 1.08-13.63), and other immunosuppression situations (OR 4.87, 95% CI 1.99-11.87) were factors independently associated with the presence of Aspergillus spp. The automatic CHAID decision tree showed that hematologic disease with an incidence of 3.3% was the most closely AI related variable. Hematological disease (OR 2.62 95% CI 1.95-3.51), immunosuppression (OR 2.05 95% CI 1.46-2.88) and AI (OR 3.24, 95% CI 1.60-6.53) were variables independently associated with ICU mortality.

Conclusions: Empirical antifungal treatment in our population may only be justified in immunocompromised patients. In moderate-high risk cases, active search for Aspergillus spp. should be implemented.

Keywords: Aspergillosis; Aspergilosis; Critically ill; Enfermo crítico; IAPA; Immunosupression; Influenza; Inmunosupresión.

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