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. 2022 Jul 22;12(7):e055470.
doi: 10.1136/bmjopen-2021-055470.

Global trends and age-specific incidence and mortality of cervical cancer from 1990 to 2019: an international comparative study based on the Global Burden of Disease

Meng Yang  1 , Juan Du  1 , Hui Lu  1 , Feiyan Xiang  1 , Hong Mei  1 , Han Xiao  2
Affiliations

Global trends and age-specific incidence and mortality of cervical cancer from 1990 to 2019: an international comparative study based on the Global Burden of Disease

Meng Yang et al. BMJ Open. .

Abstract

Objective: To describe the trends of incidence and mortality of cervical cancer in different age groups and regions from 1990 to 2019.

Design: An international comparative study based on the Global Burden of Disease (GBD) study estimates.

Participants: Data were publicly available and individuals were not involved.

Methods: We collected detailed information on cervical cancer from the GBD study between 1990 and 2019. Average annual percentage changes (AAPCs) of age-standardised incidence and mortality rate (ASIR and ASMR) in cervical cancer, by age group and region, were calculated to quantify the temporal trends.

Results: Globally, the absolute numbers of incident cases and deaths were increasing, with the most cervical cancer cases and deaths being reported in China, India and Brazil. Although the ASIR and ASMR have declined overall from 1990 to 2019, an increasing or stable trend was also observed in East Asia and Southern sub-Saharan Africa. Particularly, we found that the age-specific AAPC of incidence showed an increasing trend in the age group of 15-49 years globally, and the high Sociodemographic Index region increased the most.

Conclusions: Cervical cancer remains a concerning disease that affects women all over the world, although the ASIR and ASMR are decreasing. Efforts to control the younger trend and to reduce the disparity between regions are imminent.

Keywords: epidemiology; health policy; public health.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Absolute number of incident cases of cervical cancer for 21 Global Burden of Disease regions, from 1990 to 2019.
Figure 2
Figure 2
The ASIR in 2019 (A) and AAPC from 1990 to 2019 (B) of cervical cancer for all age groups in 195 countries and territories. AAPC, average annual percentage change; ASIR, age-standardised incidence rate.
Figure 3
Figure 3
The ASMR in 2019 (A) and AAPC from 1990 to 2019 (B) of cervical cancer for all age groups in 195 countries and territories. AAPC, average annual percentage change; ASMR, age-standardised mortality rate.
Figure 4
Figure 4
The incidence rates in 2019 (A) and AAPC from 1990 to 2019 (B) of cervical cancer in different age groups at global, regional and national levels. Error bars indicate 95% uncertainty intervals. AAPC, average annual percentage change; SDI, Sociodemographic Index.
Figure 5
Figure 5
Global numbers and rates of incident cases (A) and (B) deaths from cervical cancer by age, 2019. Error bars indicate the 95% uncertainty interval for incident cases. Shading indicates the 95% uncertainty interval for the incidence/mortality rate.
See this image and copyright information in PMC

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