Association of growth with neurodevelopment in extremely low gestational age infants: a population-based analysis

doi:10.1007/s00431-022-04567-9

. 2022 Oct;181(10):3673-3681.

doi: 10.1007/s00431-022-04567-9. Epub 2022 Jul 22.

Association of growth with neurodevelopment in extremely low gestational age infants: a population-based analysis

Affiliations

¹ Department of Neonatology, University Children's Hospital Basel UKBB, University of Basel, 4056, Basel, Switzerland. roland.gerull@ukbb.ch.
² Division of Neonatology, University Children's Hospital, University of Bern, Berne, Switzerland. roland.gerull@ukbb.ch.
³ Division of Neonatology, University Children's Hospital, University of Bern, Berne, Switzerland.
⁴ Division of Biostatistics, Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
⁵ Department Mother-Woman-Child, Clinic of Neonatology, Lausanne University Hospital and University of Lausanne (CHUV), Lausanne, Switzerland.
⁶ Department of Neonatology, Newborn Research, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
⁷ Division of Development and Growth, Department of Woman, Child and Adolescent, University Hospital, Geneva, Switzerland.
⁸ Department of Neonatology, University Children's Hospital Basel UKBB, University of Basel, 4056, Basel, Switzerland.
⁹ Family Larsson-Rosenquist Foundation Centre for Neurodevelopment, Growth and Nutrition of the Newborn, Department of Neonatology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.

PMID: 35869166
PMCID: PMC9508205
DOI: 10.1007/s00431-022-04567-9

Association of growth with neurodevelopment in extremely low gestational age infants: a population-based analysis

Roland Gerull et al. Eur J Pediatr. 2022 Oct.

. 2022 Oct;181(10):3673-3681.

doi: 10.1007/s00431-022-04567-9. Epub 2022 Jul 22.

Authors

Affiliations

¹ Department of Neonatology, University Children's Hospital Basel UKBB, University of Basel, 4056, Basel, Switzerland. roland.gerull@ukbb.ch.
² Division of Neonatology, University Children's Hospital, University of Bern, Berne, Switzerland. roland.gerull@ukbb.ch.
³ Division of Neonatology, University Children's Hospital, University of Bern, Berne, Switzerland.
⁴ Division of Biostatistics, Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
⁵ Department Mother-Woman-Child, Clinic of Neonatology, Lausanne University Hospital and University of Lausanne (CHUV), Lausanne, Switzerland.
⁶ Department of Neonatology, Newborn Research, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
⁷ Division of Development and Growth, Department of Woman, Child and Adolescent, University Hospital, Geneva, Switzerland.
⁸ Department of Neonatology, University Children's Hospital Basel UKBB, University of Basel, 4056, Basel, Switzerland.
⁹ Family Larsson-Rosenquist Foundation Centre for Neurodevelopment, Growth and Nutrition of the Newborn, Department of Neonatology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.

PMID: 35869166
PMCID: PMC9508205
DOI: 10.1007/s00431-022-04567-9

Abstract

To assess the association between postnatal growth and neurodevelopment at the age of 2 years in extremely low gestational age newborns (ELGAN, < 28 weeks' gestation). Retrospective population-based cohort study including all live born ELGAN in 2006-2012 in Switzerland. Growth parameters (weight, length, head circumference, body mass index) were assessed at birth, at hospital discharge home, and 2-year follow-up (FU2). Unadjusted and adjusted regression models assessed associations between growth (birth to hospital discharge and birth to FU2) and neurodevelopment at FU2. A total of 1244 infants (mean GA 26.5 ± 1.0 weeks, birth weight 853 ± 189 g) survived to hospital discharge and were included in the analyses. FU2 was documented for 1049 (84.3%) infants. The mean (± SD) mental and a psychomotor development index at 2FU were 88.9 (± 18.0) and 86.9 (± 17.7), respectively. Moderate or severe neurodevelopmental impairment was documented in 23.2% of patients. Changes of z-scores between birth and discharge and between birth and FU2 for weight were - 1.06 (± 0.85) and - 0.140 (± 1.15), for length - 1.36 (± 1.34), and - 0.40 (± 1.33), for head circumference - 0.61 (± 1.04) and - 0.76 (± 1.32) as well as for BMI 0.22 (± 3.36) and - 0.006 (± 1.45). Unadjusted and adjusted analyses showed that none of the four growth parameters was significantly associated with any of the three outcome parameters of neurodevelopment. This was consistent for both time intervals.

Conclusion: In the present population-based cohort of ELGAN, neither growth between birth and hospital discharge nor between birth and FU2 were significantly associated with neurodevelopment at age of 2 years.

What is known: • Studies assessing the association between growth and neurodevelopment in extremely low gestational age newborns (28 weeks' gestation) show conflicting results.

What is new: • Neither growth between birth and hospital discharge nor between birth and corrected age of 2 years were significantly associated with neurodevelopment at age of 2 years. • The role of postnatal growth as a predictor of neurodevelopmental outcome during infancy might be smaller than previously assumed.

Keywords: Development; ELGAN; Growth; Preterm.

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Conflict of interest statement

The authors declare no competing interests.

Figures

**Fig. 1**
Flow chart of patient inclusion

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References

1. Chawanpaiboon S, Vogel JP, Moller AB, Lumbiganon P, Petzold M, Hogan D, Landoulsi S, Jampathong N, Kongwattanakul K, Laopaiboon M, Lewis C, Rattanakanokchai S, Teng DN, Thinkhamrop J, Watananirun K, Zhang J, Zhou W, Gulmezoglu AM. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis. Lancet Glob Health. 2019;7:e37–e46. doi: 10.1016/S2214-109X(18)30451-0. - DOI - PMC - PubMed
1. Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R, Adler A, Vera Garcia C, Rohde S, Say L, Lawn JE. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012;379:2162–2172. doi: 10.1016/S0140-6736(12)60820-4. - DOI - PubMed
1. Serenius F, Kallen K, Blennow M, Ewald U, Fellman V, Holmstrom G, Lindberg E, Lundqvist P, Marsal K, Norman M, Olhager E, Stigson L, Stjernqvist K, Vollmer B, Stromberg B, Group E Neurodevelopmental outcome in extremely preterm infants at 2.5 years after active perinatal care in Sweden. JAMA. 2013;309:1810–1820. doi: 10.1001/jama.2013.3786. - DOI - PubMed
1. de Kieviet JF, Piek JP, Aarnoudse-Moens CS, Oosterlaan J. Motor development in very preterm and very low-birth-weight children from birth to adolescence: a meta-analysis. JAMA. 2009;302:2235–2242. doi: 10.1001/jama.2009.1708. - DOI - PubMed
1. Doyle O, Harmon CP, Heckman JJ, Tremblay RE. Investing in early human development: timing and economic efficiency. Econ Hum Biol. 2009;7:1–6. doi: 10.1016/j.ehb.2009.01.002. - DOI - PMC - PubMed

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[1] Chawanpaiboon S, Vogel JP, Moller AB, Lumbiganon P, Petzold M, Hogan D, Landoulsi S, Jampathong N, Kongwattanakul K, Laopaiboon M, Lewis C, Rattanakanokchai S, Teng DN, Thinkhamrop J, Watananirun K, Zhang J, Zhou W, Gulmezoglu AM. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis. Lancet Glob Health. 2019;7:e37–e46. doi: 10.1016/S2214-109X(18)30451-0. - DOI - PMC - PubMed

[2] Chawanpaiboon S, Vogel JP, Moller AB, Lumbiganon P, Petzold M, Hogan D, Landoulsi S, Jampathong N, Kongwattanakul K, Laopaiboon M, Lewis C, Rattanakanokchai S, Teng DN, Thinkhamrop J, Watananirun K, Zhang J, Zhou W, Gulmezoglu AM. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis. Lancet Glob Health. 2019;7:e37–e46. doi: 10.1016/S2214-109X(18)30451-0. - DOI - PMC - PubMed

[3] Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R, Adler A, Vera Garcia C, Rohde S, Say L, Lawn JE. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012;379:2162–2172. doi: 10.1016/S0140-6736(12)60820-4. - DOI - PubMed

[4] Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R, Adler A, Vera Garcia C, Rohde S, Say L, Lawn JE. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012;379:2162–2172. doi: 10.1016/S0140-6736(12)60820-4. - DOI - PubMed

[5] Serenius F, Kallen K, Blennow M, Ewald U, Fellman V, Holmstrom G, Lindberg E, Lundqvist P, Marsal K, Norman M, Olhager E, Stigson L, Stjernqvist K, Vollmer B, Stromberg B, Group E Neurodevelopmental outcome in extremely preterm infants at 2.5 years after active perinatal care in Sweden. JAMA. 2013;309:1810–1820. doi: 10.1001/jama.2013.3786. - DOI - PubMed

[6] Serenius F, Kallen K, Blennow M, Ewald U, Fellman V, Holmstrom G, Lindberg E, Lundqvist P, Marsal K, Norman M, Olhager E, Stigson L, Stjernqvist K, Vollmer B, Stromberg B, Group E Neurodevelopmental outcome in extremely preterm infants at 2.5 years after active perinatal care in Sweden. JAMA. 2013;309:1810–1820. doi: 10.1001/jama.2013.3786. - DOI - PubMed

[7] de Kieviet JF, Piek JP, Aarnoudse-Moens CS, Oosterlaan J. Motor development in very preterm and very low-birth-weight children from birth to adolescence: a meta-analysis. JAMA. 2009;302:2235–2242. doi: 10.1001/jama.2009.1708. - DOI - PubMed

[8] de Kieviet JF, Piek JP, Aarnoudse-Moens CS, Oosterlaan J. Motor development in very preterm and very low-birth-weight children from birth to adolescence: a meta-analysis. JAMA. 2009;302:2235–2242. doi: 10.1001/jama.2009.1708. - DOI - PubMed

[9] Doyle O, Harmon CP, Heckman JJ, Tremblay RE. Investing in early human development: timing and economic efficiency. Econ Hum Biol. 2009;7:1–6. doi: 10.1016/j.ehb.2009.01.002. - DOI - PMC - PubMed

[10] Doyle O, Harmon CP, Heckman JJ, Tremblay RE. Investing in early human development: timing and economic efficiency. Econ Hum Biol. 2009;7:1–6. doi: 10.1016/j.ehb.2009.01.002. - DOI - PMC - PubMed

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Association of growth with neurodevelopment in extremely low gestational age infants: a population-based analysis

Affiliations

Association of growth with neurodevelopment in extremely low gestational age infants: a population-based analysis

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

References

MeSH terms

LinkOut - more resources

Full Text Sources

Abstract

Conflict of interest statement

Figures

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References

MeSH terms

Related information

LinkOut - more resources

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