Reaching for the unreachable: low intensity focused ultrasound for non-invasive deep brain stimulation

doi:10.1038/s41386-022-01386-2

. 2023 Jan;48(1):251-252.

doi: 10.1038/s41386-022-01386-2.

Reaching for the unreachable: low intensity focused ultrasound for non-invasive deep brain stimulation

Noah S Philip^{1

2}, Amanda R Arulpragasam^{3

4}

Affiliations

¹ VA RR&D Center for Neurorestoration and Neurotechnology, VA Providence, Providence, RI, USA. Noah_Philip@Brown.edu.
² Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA. Noah_Philip@Brown.edu.
³ VA RR&D Center for Neurorestoration and Neurotechnology, VA Providence, Providence, RI, USA.
⁴ Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.

PMID: 35869281
PMCID: PMC9700833
DOI: 10.1038/s41386-022-01386-2

Reaching for the unreachable: low intensity focused ultrasound for non-invasive deep brain stimulation

Noah S Philip et al. Neuropsychopharmacology. 2023 Jan.

. 2023 Jan;48(1):251-252.

doi: 10.1038/s41386-022-01386-2.

Authors

Noah S Philip^{1

2}, Amanda R Arulpragasam^{3

4}

Affiliations

¹ VA RR&D Center for Neurorestoration and Neurotechnology, VA Providence, Providence, RI, USA. Noah_Philip@Brown.edu.
² Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA. Noah_Philip@Brown.edu.
³ VA RR&D Center for Neurorestoration and Neurotechnology, VA Providence, Providence, RI, USA.
⁴ Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.

PMID: 35869281
PMCID: PMC9700833
DOI: 10.1038/s41386-022-01386-2

No abstract available

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Conflict of interest statement

The authors declare no competing interests.

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References

1. Arulpragasam AR, et al. Low intensity focused ultrasound for non-invasive and reversible deep brain neuromodulation-A paradigm shift in psychiatric research. Front Psychiatry. 2022;13:825802. doi: 10.3389/fpsyt.2022.825802. - DOI - PMC - PubMed
1. Dell’Italia J, et al. Current state of potential mechanisms supporting low intensity focused ultrasound for neuromodulation. Front Hum Neurosci. 2022;16:872639. doi: 10.3389/fnhum.2022.872639. - DOI - PMC - PubMed
1. Folloni D, et al. Manipulation of subcortical and deep cortical activity in the primate brain using transcranial focused ultrasound stimulation. Neuron. 2019;101:1109–1116. doi: 10.1016/j.neuron.2019.01.019. - DOI - PMC - PubMed
1. Legon W, et al. Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans. Nat Neurosci. 2014;17:322–9. doi: 10.1038/nn.3620. - DOI - PubMed
1. Badran BW, et al. Sonication of the anterior thalamus with MRI-Guided transcranial focused ultrasound (tFUS) alters pain thresholds in healthy adults: A double-blind, sham-controlled study. Brain Stimul. 2020;13:1805–12. doi: 10.1016/j.brs.2020.10.007. - DOI - PMC - PubMed

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[1] Arulpragasam AR, et al. Low intensity focused ultrasound for non-invasive and reversible deep brain neuromodulation-A paradigm shift in psychiatric research. Front Psychiatry. 2022;13:825802. doi: 10.3389/fpsyt.2022.825802. - DOI - PMC - PubMed

[2] Arulpragasam AR, et al. Low intensity focused ultrasound for non-invasive and reversible deep brain neuromodulation-A paradigm shift in psychiatric research. Front Psychiatry. 2022;13:825802. doi: 10.3389/fpsyt.2022.825802. - DOI - PMC - PubMed

[3] Dell’Italia J, et al. Current state of potential mechanisms supporting low intensity focused ultrasound for neuromodulation. Front Hum Neurosci. 2022;16:872639. doi: 10.3389/fnhum.2022.872639. - DOI - PMC - PubMed

[4] Dell’Italia J, et al. Current state of potential mechanisms supporting low intensity focused ultrasound for neuromodulation. Front Hum Neurosci. 2022;16:872639. doi: 10.3389/fnhum.2022.872639. - DOI - PMC - PubMed

[5] Folloni D, et al. Manipulation of subcortical and deep cortical activity in the primate brain using transcranial focused ultrasound stimulation. Neuron. 2019;101:1109–1116. doi: 10.1016/j.neuron.2019.01.019. - DOI - PMC - PubMed

[6] Folloni D, et al. Manipulation of subcortical and deep cortical activity in the primate brain using transcranial focused ultrasound stimulation. Neuron. 2019;101:1109–1116. doi: 10.1016/j.neuron.2019.01.019. - DOI - PMC - PubMed

[7] Legon W, et al. Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans. Nat Neurosci. 2014;17:322–9. doi: 10.1038/nn.3620. - DOI - PubMed

[8] Legon W, et al. Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans. Nat Neurosci. 2014;17:322–9. doi: 10.1038/nn.3620. - DOI - PubMed

[9] Badran BW, et al. Sonication of the anterior thalamus with MRI-Guided transcranial focused ultrasound (tFUS) alters pain thresholds in healthy adults: A double-blind, sham-controlled study. Brain Stimul. 2020;13:1805–12. doi: 10.1016/j.brs.2020.10.007. - DOI - PMC - PubMed

[10] Badran BW, et al. Sonication of the anterior thalamus with MRI-Guided transcranial focused ultrasound (tFUS) alters pain thresholds in healthy adults: A double-blind, sham-controlled study. Brain Stimul. 2020;13:1805–12. doi: 10.1016/j.brs.2020.10.007. - DOI - PMC - PubMed

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Reaching for the unreachable: low intensity focused ultrasound for non-invasive deep brain stimulation

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Reaching for the unreachable: low intensity focused ultrasound for non-invasive deep brain stimulation

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