Polyelectrolyte Hydrogels for Tissue Engineering and Regenerative Medicine

Chen-Gang Wang¹, Nayli Erdeanna Binte Surat'man¹, Jun Jie Chang², Zhi Lin Ong^{2

3}, Bofan Li¹, Xiaotong Fan¹, Xian Jun Loh², Zibiao Li^{1

2

4}

Affiliations

¹ Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Singapore, 138634, Singapore.
² Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Singapore, 138634, Singapore.
³ School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459, Singapore.
⁴ Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore, 117576, Singapore.

PMID: 35869819
DOI: 10.1002/asia.202200604

Review

Polyelectrolyte Hydrogels for Tissue Engineering and Regenerative Medicine

Chen-Gang Wang et al. Chem Asian J. 2022.

. 2022 Sep 14;17(18):e202200604.

doi: 10.1002/asia.202200604. Epub 2022 Aug 10.

Authors

Chen-Gang Wang¹, Nayli Erdeanna Binte Surat'man¹, Jun Jie Chang², Zhi Lin Ong^{2

3}, Bofan Li¹, Xiaotong Fan¹, Xian Jun Loh², Zibiao Li^{1

2

4}

Affiliations

¹ Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Singapore, 138634, Singapore.
² Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Singapore, 138634, Singapore.
³ School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459, Singapore.
⁴ Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore, 117576, Singapore.

PMID: 35869819
DOI: 10.1002/asia.202200604

Abstract

Polyelectrolyte hydrogels are emerging materials for tissue engineering and regenerative medicine applications due to their tunable biochemical properties, electrical conductivity, biocompatibility and similar network structure to the extracellular matrix in mammalian bodies. In this review, representative polyelectrolyte hydrogels carrying anionic, cationic, ampholytic, zwitterionic and ionic liquid moieties are systemically cataloged to express their chemical structures and preparation strategies. Recent advance of polyelectrolyte hydrogels in tissue engineering and regenerative medicine for drug delivery, skin healing, bone regeneration, cardiac tissue repair and anti-biofouling coating are also highlighted. Eventually, the outlook and challenges of polyelectrolyte hydrogels and their biomedical material applications are also discussed to offer future directions.

Keywords: cellular therapy; cross-linked polymers; hydrogels; polyelectrolyte; regenerative medicine; tissue engineering.

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Polyelectrolyte Hydrogels for Tissue Engineering and Regenerative Medicine

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Polyelectrolyte Hydrogels for Tissue Engineering and Regenerative Medicine

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