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. 2022 Nov;8(11):887-889.
doi: 10.1016/j.trecan.2022.06.012. Epub 2022 Jul 21.

Revisiting the concept of childhood preleukemia

Cesar Cobaleda  1 , Carolina Vicente-Dueñas  2 , Manuel Ramírez-Orellana  3 , Isidro Sanchez-Garcia  4
Affiliations

Revisiting the concept of childhood preleukemia

Cesar Cobaleda et al. Trends Cancer. 2022 Nov.

Abstract

Preleukemic has been used to describe children with a propensity to develop B cell acute lymphoblastic leukemia (B-ALL). However, leukemia-predisposing mutations can also be present in differentiated cells unable to transform. We postulate that preleukemia should only be used when such mutations arise in progenitors capable of evolving to B-ALL.

Keywords: childhood leukemia; genetic predisposition; mouse models; preclinical; prevention.

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Declaration of interests No interests are declared.

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