Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Jul 23;7(1):249.
doi: 10.1038/s41392-022-01121-9.

Trilateral interaction between innervation, leukocyte, and adventitia: a new driver of atherosclerotic plaque formation

Yahya Sohrabi  1   2 , Holger Reinecke  3 , Oliver Soehnlein  4   5
Affiliations
Comment

Trilateral interaction between innervation, leukocyte, and adventitia: a new driver of atherosclerotic plaque formation

Yahya Sohrabi et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

O.S. is the advisor for ResoTher and Novo Nordisk and receives funding from Novo Nordisk to study chronopharmacological and histone-neutralizing strategies in atherosclerosis.

Figures

Fig. 1
Fig. 1
Denervation attenuates atherosclerosis. Stress and pain may trigger atherosclerosis via activating the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis. Mental stress alters immune cell balance in the circulation and promotes myelopoiesis in the bone marrow and spleen. Activation of the SNS promotes artery-associated tertiary lymphoid organ (ATLO) formation and induces axonogenesis around adventitia adjacent to plaque segments. Sympathectomy and denervation reduces atherosclerosis by reducing the number, size, and cellularity of ATLOs as well as plaque formation (indicated by blue color). It also decreases infiltrating cells into the plaques and improves the hematopoietic stem cells profile as well as circulating cell numbers. The figure was created with BioRender.com
See this image and copyright information in PMC

Comment on

  • Neuroimmune cardiovascular interfaces control atherosclerosis.
    Mohanta SK, Peng L, Li Y, Lu S, Sun T, Carnevale L, Perrotta M, Ma Z, Förstera B, Stanic K, Zhang C, Zhang X, Szczepaniak P, Bianchini M, Saeed BR, Carnevale R, Hu D, Nosalski R, Pallante F, Beer M, Santovito D, Ertürk A, Mettenleiter TC, Klupp BG, Megens RTA, Steffens S, Pelisek J, Eckstein HH, Kleemann R, Habenicht L, Mallat Z, Michel JB, Bernhagen J, Dichgans M, D'Agostino G, Guzik TJ, Olofsson PS, Yin C, Weber C, Lembo G, Carnevale D, Habenicht AJR. Mohanta SK, et al. Nature. 2022 May;605(7908):152-159. doi: 10.1038/s41586-022-04673-6. Epub 2022 Apr 27. Nature. 2022. PMID: 35477759

References

    1. Mohanta SK, et al. Neuroimmune cardiovascular interfaces control atherosclerosis. Nature. 2022;605:152–159. doi: 10.1038/s41586-022-04673-6. - DOI - PubMed
    1. Soehnlein O, Libby P. Targeting inflammation in atherosclerosis—from experimental insights to the clinic. Nat. Rev. Drug Discov. 2021;20:589–610. doi: 10.1038/s41573-021-00198-1. - DOI - PMC - PubMed
    1. Hinterdobler J, et al. Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis. Eur. Heart J. 2021;42:4077–4088. doi: 10.1093/eurheartj/ehab371. - DOI - PMC - PubMed
    1. de Juan A, et al. Artery-associated sympathetic innervation drives rhythmic vascular inflammation of arteries and veins. Circulation. 2019;140:1100–1114. doi: 10.1161/CIRCULATIONAHA.119.040232. - DOI - PMC - PubMed
    1. Poller, W. C. et al. Brain motor and fear circuits regulate leukocytes during acute stress. Nature10.1038/s41586-022-04890-z (2022). - PMC - PubMed

Publication types