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Comment
. 2022 Jul 23;7(1):250.
doi: 10.1038/s41392-022-01112-w.

SARS-CoV-2 infection of monocytes: balancing acts of antibodies and inflammasomes

R Camille Brewer  1   2 , William H Robinson  1   2 , Tobias V Lanz  3   4
Affiliations
Comment

SARS-CoV-2 infection of monocytes: balancing acts of antibodies and inflammasomes

R Camille Brewer et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Antibody-mediated SARS-CoV-2 infection of monocytes via FcγRs. a Immune complexes composed of afucosylated anti-SARS-CoV-2 IgG and virus infect monocytes via FcγRIIIa and FcγRI, which initiates b phagocytosis. c SARS-CoV-2 escapes degradation via the phagolysosome and initiates replication in the cytoplasm. d Replication of SARS-CoV-2 activates NLRP3 and AIM2 leading to the formation of e the NLRP3 and AIM2 inflammasome complex. f Inflammasome activation induces cleavage of pro-IL-1β and pro-IL-18 resulting in the release of pro-inflammatory cytokines IL-1β and IL-18. g Gasdermin D (GSDMD) is cleaved and inserted into the membrane instigating pyroptosis. h Inflammasome activation and pyroptotic cell death halt SARS-CoV-2 replication. i Secretion of IL-1β and IL-18 and pyroptosis contribute to systematic inflammation, associated with severe COVID-19. GSDMD amino-terminal cell death domain (GSDMDNterm)
See this image and copyright information in PMC

Comment on

  • FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation.
    Junqueira C, Crespo Â, Ranjbar S, de Lacerda LB, Lewandrowski M, Ingber J, Parry B, Ravid S, Clark S, Schrimpf MR, Ho F, Beakes C, Margolin J, Russell N, Kays K, Boucau J, Das Adhikari U, Vora SM, Leger V, Gehrke L, Henderson LA, Janssen E, Kwon D, Sander C, Abraham J, Goldberg MB, Wu H, Mehta G, Bell S, Goldfeld AE, Filbin MR, Lieberman J. Junqueira C, et al. Nature. 2022 Jun;606(7914):576-584. doi: 10.1038/s41586-022-04702-4. Epub 2022 Apr 6. Nature. 2022. PMID: 35385861 Free PMC article.

References

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