SARS-CoV-2 infection in severe asthma is associated with worsening of COVID-19 through respiratory NLRP3 inflammasome activation

Jae Seok Jeong^{1

2}, Jin Young Choi³, Jong Seung Kim^{4

5}, Seong Ok Park³, Wankyu Kim^{6

7}, Yeo-Gha Yoon⁶, Hae Jin Park¹, Kyung Hwa Park¹, Doo Hwan Kim^{8

9}, Jung Mo Kim¹⁰, Gou Young Koh^{10

11}, Seong Kug Eo³, Yong Chul Lee^{1

2}

Affiliations

¹ Department of Internal Medicine, Research Center for Pulmonary Disorders, Jeonbuk National University Medical School, Jeonju, South Korea.
² Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea.
³ College of Veterinary Medicine and Zoonosis Research Institute, Jeonbuk National University, Iksan, South Korea.
⁴ Department of Otorhinolaryngology-Head and Neck Surgery, Jeonbuk National University Medical School, Jeonju, South Korea.
⁵ Department of Medical Informatics, Jeonbuk National University Medical School, Jeonju, South Korea.
⁶ Department of Life Sciences, Ewha Womans University, Seoul, South Korea.
⁷ Kaipharm, Seoul, South Korea.
⁸ National Health Insurance Service (NHIS), Wonju, South Korea.
⁹ Basgenbio Inc., Seoul, South Korea.
¹⁰ Center for Vascular Research, Institute for Basic Science (IBS), Daejeon, South Korea.
¹¹ Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.

PMID: 35871401
PMCID: PMC9349818
DOI: 10.1111/all.15452

Comment

SARS-CoV-2 infection in severe asthma is associated with worsening of COVID-19 through respiratory NLRP3 inflammasome activation

Jae Seok Jeong et al. Allergy. 2023 Jan.

. 2023 Jan;78(1):287-290.

doi: 10.1111/all.15452. Epub 2022 Aug 5.

Authors

Affiliations

¹ Department of Internal Medicine, Research Center for Pulmonary Disorders, Jeonbuk National University Medical School, Jeonju, South Korea.
² Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea.
³ College of Veterinary Medicine and Zoonosis Research Institute, Jeonbuk National University, Iksan, South Korea.
⁴ Department of Otorhinolaryngology-Head and Neck Surgery, Jeonbuk National University Medical School, Jeonju, South Korea.
⁵ Department of Medical Informatics, Jeonbuk National University Medical School, Jeonju, South Korea.
⁶ Department of Life Sciences, Ewha Womans University, Seoul, South Korea.
⁷ Kaipharm, Seoul, South Korea.
⁸ National Health Insurance Service (NHIS), Wonju, South Korea.
⁹ Basgenbio Inc., Seoul, South Korea.
¹⁰ Center for Vascular Research, Institute for Basic Science (IBS), Daejeon, South Korea.
¹¹ Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.

PMID: 35871401
PMCID: PMC9349818
DOI: 10.1111/all.15452

No abstract available

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Comment on

Asthma phenotypes, associated comorbidities, and long-term symptoms in COVID-19.
Eggert LE, He Z, Collins W, Lee AS, Dhondalay G, Jiang SY, Fitzpatrick J, Snow TT, Pinsky BA, Artandi M, Barman L, Puri R, Wittman R, Ahuja N, Blomkalns A, O'Hara R, Cao S, Desai M, Sindher SB, Nadeau K, Chinthrajah RS. Eggert LE, et al. Allergy. 2022 Jan;77(1):173-185. doi: 10.1111/all.14972. Epub 2021 Jun 19. Allergy. 2022. PMID: 34080210 Free PMC article.

References

REFERENCES

1. Eggert LE, He Z, Collins W, et al. Asthma phenotypes, associated comorbidities, and long-term symptoms in COVID-19. Allergy. 2022;77(1):173-185.
1. Bloom CI, Cullinan P, Wedzicha JA. Asthma phenotypes and COVID-19 risk: a population-based observational study. Am J Respir Crit Care Med. 2022;205(1):36-45.
1. Zheng J, Wong LR, Li K, et al. COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice. Nature. 2021;589(7843):603-607.
1. Jeong JS, Lee KB, Kim SR, et al. Airway epithelial phosphoinositide 3-kinase-δ contributes to the modulation of fungi-induced innate immune response. Thorax. 2018;73(8):758-768.
1. Vora SM, Lieberman J, Wu H. Inflammasome activation at the crux of severe COVID-19. Nat Rev Immunol. 2021;21(11):694-703.

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SARS-CoV-2 infection in severe asthma is associated with worsening of COVID-19 through respiratory NLRP3 inflammasome activation

Affiliations

SARS-CoV-2 infection in severe asthma is associated with worsening of COVID-19 through respiratory NLRP3 inflammasome activation

Authors

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References

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