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. 2022 Dec;22(12):2912-2920.
doi: 10.1111/ajt.17159. Epub 2022 Aug 3.

Awarding additional MELD points to the shortest waitlist candidates improves sex disparity in access to liver transplant in the United States

Sarah Bernards  1 , Eric Lee  1 , Ngai Leung  2 , Mustafa Akan  3 , Kyra Gan  3 , Huan Zhao  2 , Monika Sarkar  1 , Sridhar Tayur  3 , Neil Mehta  1
Affiliations
Free article

Awarding additional MELD points to the shortest waitlist candidates improves sex disparity in access to liver transplant in the United States

Sarah Bernards et al. Am J Transplant. 2022 Dec.
Free article

Abstract

Since the introduction of the MELD-based allocation system, women are now 30% less likely than men to undergo liver transplant (LT) and have 20% higher waitlist mortality. These disparities are in large part due to height differences in men and women though no national policies have been implemented to reduce sex disparities. Patients were identified using the Scientific Registry of Transplant Recipients (SRTR) from 2014 to 2019. Patients were categorized into five groups by first dividing into thirds by height then dividing the shortest third into three groups to capture more granular differences in the most disadvantaged patients (<166 cm). We then used LSAM to model waitlist outcomes in five versions of awarding additional MELD points to shorter candidates compared to current policy. We identified two proposed policy changes LSAM scenarios that resulted in improvement in LT and death percentage for the shortest candidates with the least negative impact on taller candidates. In conclusion, awarding an additional 1-2 MELD points to the shortest 8% of LT candidates would improve waitlist outcomes for women. This strategy should be considered in national policy allocation to address sex-based disparities in LT.

Keywords: United Network for Organ Sharing (UNOS); cirrhosis; classification systems: Model for Endstage Liver Disease (MELD); clinical research/practice; gender; health services and outcomes research; liver transplantation/hepatology; organ allocation.

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References

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