Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct;3(10):e729.
doi: 10.1016/S2666-5247(22)00193-8. Epub 2022 Jul 21.

Finite neutralisation breadth of omicron after repeated vaccination

Affiliations

Finite neutralisation breadth of omicron after repeated vaccination

Yufang Zhu et al. Lancet Microbe. 2022 Oct.
No abstract available

PubMed Disclaimer

Conflict of interest statement

This study was supported by US Department of Veterans Affairs (grant 5I01BX001353 to PH). Funding sources have no role in the study and manuscript preparation. YZ and YL contributed equally. YZ, ZC, CZ, and RL recruited participants, collected specimens, did the clinical laboratory tests, and interpreted findings; YL and LT did the neutralisation assays and assisted statistical analyses; YX and ZZ interpreted findings and revised the manuscript; MC guided statistical analysis and did the data quality checks; PH conceived and designed the study, did the statistical analysis, and wrote the manuscript. No authors were precluded from accessing data in the study, and they accept responsibility to submit for publication. All authors read and approve the final manuscript. YZ and YL contributed equally. We thank the nurses and technicians at the Division of Laboratory Medicine at Xiangyang Central Hospital for their assistance in participant enrollment, blood collection, and sample preparation. We declare no competing interests.

References

    1. Muecksch F, Wang Z, Cho A, et al. Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost. Nature. 2022;607:128–134. - PMC - PubMed
    1. Nyberg T, Ferguson NM, Nash SG, et al. Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study. Lancet. 2022;399:1303–1312. - PMC - PubMed
    1. Hardès V, Vergassola M, Walczak AM, Mora T. Affinity maturation for an optimal balance between long-term immune coverage and short-term resource constraints. Proc Natl Acad Sci USA. 2022;119 - PMC - PubMed
    1. Lu Y, Zhu Y, Cui M, Cheng Z, Hong P. Post-recovery enhancement of anti-variant neutralisation after severe COVID-19. Lancet Microbe. 2022;3:e330–e331. - PMC - PubMed
    1. Walls AC, Sprouse KR, Bowen JE, et al. SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses. Cell. 2022;185:872–880. - PMC - PubMed

Publication types

MeSH terms