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. 2022 Oct;60(4):106641.
doi: 10.1016/j.ijantimicag.2022.106641. Epub 2022 Jul 22.

The ingredients for an antimicrobial mathematical modelling broth

Marcus Tindall  1 , Michael J Chappell  2 , James W T Yates  3
Affiliations

The ingredients for an antimicrobial mathematical modelling broth

Marcus Tindall et al. Int J Antimicrob Agents. 2022 Oct.

Abstract

Mathematical modelling has made significant contributions to the optimization of the use of antimicrobial treatments. This article discusses the key processes that such mathematical modelling should attempt to capture. In particular, this article highlights that the response of the host immune system requires quantification, and this is illustrated with a novel model structure.

Keywords: Drug resistance; Mathematical modelling; Pharmacodynamics; Pharmacokinetics.

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Conflict of interest statement

Competing of Interests None declared.

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