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. 1987 May;10(4):359-62.
doi: 10.1002/mus.880100413.

Serotonin uptake in blood platelets of Duchenne muscular dystrophy patients

R C Arora, R W Kuncl, J Morgan, L Cohen, H Y Meltzer

Serotonin uptake in blood platelets of Duchenne muscular dystrophy patients

R C Arora et al. Muscle Nerve. 1987 May.

Abstract

Serotonin (5-HT) uptake was studied in the blood platelets of 10 patients with Duchenne-type muscular dystrophy (DMD) and 7 age-matched controls. Vmax (maximum number of uptake sites) of platelet 5-HT uptake in the DMD patients was significantly less than that of the normal controls. There was no difference in the affinity for 5-HT (Km) between the two groups. There was a significant negative correlation between serum creatine kinase activity and Km of 5-HT uptake in blood platelets of these patients. However, no correlation was found between Km or Vmax and ambulatory status of DMD.

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