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Review
. 2022 Jul 8:10:935894.
doi: 10.3389/fchem.2022.935894. eCollection 2022.

Research Progress on Structure and Anti-Gynecological Malignant Tumor of Shikonin

Li-Na Ke  1 , Ling-Qi Kong  2 , Huan-Huan Xu  1 , Qin-Hua Chen  3 , Yun Dong  1 , Bin Li  1 , Xiao-Hua Zeng  2 , Hong-Mei Wang  1   2
Affiliations
Review

Research Progress on Structure and Anti-Gynecological Malignant Tumor of Shikonin

Li-Na Ke et al. Front Chem. .

Abstract

Gynecological malignancy seriously threatens the physical and mental health of women. Shikonin is a naphthoquinone compound with a variety of biological activities. Studies have shown that shikonin can inhibit cell proliferation, promote cell apoptosis and induce cell necrosis. And in recent years, shikonin are also being increasingly used for the study of gynecological malignant diseases. Therefore, we reviewed the mechanism of action and structure optimization of shikonin in gynecological malignant tumors, in order to provide some reference for further research and development of related drug.

Keywords: anti-cancer; gynecological malignancy; review; shikonin; structural modification.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Chemical structures of shikonin and alkannin.
FIGURE 2
FIGURE 2
The signaling pathway of shikonin against gynecological malignant tumor.
FIGURE 3
FIGURE 3
Synthesis of shikonin derivatives with arylsulfonamides side chains.
FIGURE 4
FIGURE 4
Synthesis of shikonin oxime derivatives.
FIGURE 5
FIGURE 5
Synthesis of acetyl-β-glycosylshikonins.
See this image and copyright information in PMC

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