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. 1987;327(6120):293-7.
doi: 10.1038/327293a0.

Prevalence of ras gene mutations in human colorectal cancers

J L Bos, E R Fearon, S R Hamilton, M Verlaan-de Vries, J H van Boom, A J van der Eb, B Vogelstein

Prevalence of ras gene mutations in human colorectal cancers

J L Bos et al. Nature. 1987.

Abstract

A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.

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