Micro (mi) RNA and Diabetic Retinopathy

Abstract

Diabetic Retinopathy (DR), a debilitating microvascular complication of diabetes, is one of the leading cause of blindness. However, the pathogenesis of this disease is not fully understood. Few Studies have reported the role of MicroRNA (miRNA), which is deregulated or altered in many diseases. Further, few pathways linked genes which have been suggested to be regulated by miRNAs, may play an important role in the regulation of glucose homeostasis and eventually may contribute to the establishment of DR. However, the roles of microRNAs (miRNAs) in DR are still not very clear. In current review, we explored various findings of scientific database demonstrating the role of miRNA in the progression and development of Diabetic Retinopathy.

Keywords: Diabetic retinopathy; Glucose; Mi RNA.

Fig. 1

a primary miRNA (pri-miRNA) transcript is encoded in the cell's DNA and transcribed in the nucleus, processed by an enzyme Dosha and exported into the cytoplasm where it is further processed by Dicer. After strand separation, the mature miRNA represses protein production either by blocking translation or causing transcript degradation [88]. b Upregulated or down regulated miRNA causes diabetic retinopathy