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Review
. 2022 Jul 15:15:1357-1366.
doi: 10.2147/CCID.S289750. eCollection 2022.

Androgen Receptor Inhibitors in the Treatment of Acne Vulgaris: Efficacy and Safety Profiles of Clascoterone 1% Cream

Carol Sanchez  1 , Jonette Keri  1   2
Affiliations
Review

Androgen Receptor Inhibitors in the Treatment of Acne Vulgaris: Efficacy and Safety Profiles of Clascoterone 1% Cream

Carol Sanchez et al. Clin Cosmet Investig Dermatol. .

Abstract

The purpose of this narrative review is to provide a summary of the clinical trials on the efficacy and safety of clascoterone 1% cream (Winlevi) to grant providers an understanding of which patients will benefit most from this novel topical antiandrogen medication. Clascoterone 1% cream (Winlevi) offers a new and exciting treatment approach for a difficult and common skin condition such as acne vulgaris. This topical androgen antagonist is the first of its kind but will hopefully provoke investigations into other androgen receptor antagonists with similar or better efficacy.

Keywords: CB-03-01; Winlevi; anti-androgens; hormonal acne.

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Conflict of interest statement

Dr Jonette Keri reports being a consultant for Almirall, being on the advisory board for Ortho dermatologics, research study from Galderma, during the conduct of the study. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Chemical structures of clascoterone (left) and spironolactone (right) created with MolView an open-source web-application. Both structures are steroid structures that are comprised of a four-ring backbone: three cyclohexane rings and one cyclopentane ring. The molecular formula for clascoterone is  C24H34O5, whereas the molecular formula for spironolactone is C24H32O4S.
See this image and copyright information in PMC

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