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Review
. 2022 Jul 8:10:937528.
doi: 10.3389/fped.2022.937528. eCollection 2022.

Linear Immunoglobulin a Bullous Dermatosis in Children

Francesca Mori  1 , Francesca Saretta  2 , Lucia Liotti  3 , Mattia Giovannini  1 , Riccardo Castagnoli  4 , Stefania Arasi  5 , Simona Barni  1 , Carla Mastrorilli  6 , Luca Pecoraro  7 , Lucia Caminiti  8 , Gian Luigi Marseglia  4 , Annick Barbaud  9 , Elio Novembre  1
Affiliations
Review

Linear Immunoglobulin a Bullous Dermatosis in Children

Francesca Mori et al. Front Pediatr. .

Abstract

Linear Immunoglobulin A Bullous Disease (LABD) is a rare dermatosis whose pathomechanisms are not yet completely understood. LABD has different features characterizing adults and children in terms of potential triggers, clinical manifestations, and prognosis. The aim of the present study is to review all neonatal and pediatric cases of LABD and summarize the major characteristics. Childhood LABD is mainly idiopathic with a benign prognosis. Neonatal cases are difficult to differentiate from infectious diseases and usually have a poor prognosis. Drugs are one of the possible triggers that can activate autoimmune responses through antigen mimicry and epitope spreading as well as different stimuli (e.g., infections, inflammatory diseases, trauma). The gold standard for the diagnosis is based on direct immunofluorescence. Prognosis is generally favorable but often depends on the prompt dermatological diagnosis, treatment and follow-up guaranteed by a multidisciplinary team, including pediatricians for this group of age.

Keywords: children; diagnosis; drug hypersensitivity; epidemiology; linear IgA bullous dermatosis (LABD); newborn; treatment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Typical lesions of LABD known as “string of pearls” in a girl evaluated at Meyer's Children Hospital (Florence).
Figure 2
Figure 2
Magnification of typical LABD lesions on the same patient.
See this image and copyright information in PMC

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