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Review
. 2022 Jul 8:10:954536.
doi: 10.3389/fcell.2022.954536. eCollection 2022.

Mitochondrial-Dependent and Independent Functions of PINK1

Xiusheng Chen  1 , Qi Wang  1 , Shihua Li  1 , Xiao-Jiang Li  1 , Weili Yang  1
Affiliations
Review

Mitochondrial-Dependent and Independent Functions of PINK1

Xiusheng Chen et al. Front Cell Dev Biol. .

Abstract

PINK1 has been characterized as a mitochondrial kinase that can target to damaged mitochondria to initiate mitophagy, a process to remove unhealthy mitochondria for protecting neuronal cells. Mutations of the human PINK1 gene are also found to cause early onset Parkinson's disease, a neurodegenerative disorder with the pathological feature of mitochondrial dysfunction. Despite compelling evidence from in vitro studies to support the role of PINK1 in regulation of mitochondrial function, there is still lack of strong in vivo evidence to validate PINK1-mediated mitophagy in the brain. In addition, growing evidence indicates that PINK1 also executes function independent of mitochondria. In this review, we discuss the mitochondrial dependent and independent functions of PINK1, aiming at elucidating how PINK1 functions differentially under different circumstances.

Keywords: PINK1; Parkinson’s disease (PD); mitochondria; mitophagy; parkin (PARK2).

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Full-length PINK1 is able to target to mitochondria and is cleaved by proteases to generate cytosolic form of PINK1 upon mitochondria damage. Lack of in vivo evidence for PINK1-mediated mitophagy.
FIGURE 2
FIGURE 2
Mitochondrial-dependent and independent functions of PINK1. In the primate brain, PINK1 can phosphorylate a large number of proteins, including those for regulating mitochondrial function, to maintain neuronal survival.
See this image and copyright information in PMC

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