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. 1978 Aug;86C(4):199-201.
doi: 10.1111/j.1699-0463.1978.tb02579.x.

Immunosuppressive effect of human pregnancy zone protein on H-2 incompatible mouse heart allografts

P Svendsen, T Stigbrand, B Teisner, J Folkersen, M G Damber, B von Schoultz, E Kemp, S E Svehag

Immunosuppressive effect of human pregnancy zone protein on H-2 incompatible mouse heart allografts

P Svendsen et al. Acta Pathol Microbiol Scand C. 1978 Aug.

Abstract

Human pregnancy zone protein (PZP) given intraveneously, significantly (p less than 0.001) prolonged the survival of heterotopic A/J heart transplants in A.CA recipients, compared to untreated control recipients, recipients treated with phosphate buffered saline and recipients treated with a control preparation from male serum. The results support the hypothesis that PZP protein exerts an unspecific immunosuppressive effect in vivo.

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