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. 2022 Jul 20:46:e108.
doi: 10.26633/RPSP.2022.108. eCollection 2022.

[Neurocovid-19: effects of COVID-19 on the brainNeurocovid-19: efeitos da COVID-19 no cérebro]

[Article in Spanish]
Shadye Matar-Khalil  1
Affiliations

[Neurocovid-19: effects of COVID-19 on the brainNeurocovid-19: efeitos da COVID-19 no cérebro]

[Article in Spanish]
Shadye Matar-Khalil. Rev Panam Salud Publica. .

Abstract
in English, Spanish, Portuguese

In the COVID-19 pandemic, direct and indirect effects on mental health have been reported, including neurological, neuropsychiatric, and neuropsychological symptoms with possible long-term effects. Also, it is suspected that in the coming years there could be a worldwide increase in the incidence of neurodegenerative disorders.The objective of this article is to review the most up-to-date information on brain damage associated with COVID-19, as well as the neuropsychiatric symptoms of the disease. The exact mechanisms of brain damage have not yet been clarified, and further longitudinal and international research-including studies that incorporate epidemiological, clinical, and diagnostic variables-is required to define these mechanisms and establish their impact on mental health, as well as their long-term consequences.

En la pandemia por COVID-19 se han reportado efectos directos e indirectos sobre la salud mental, inclusive sintomatología neurológica, neuropsiquiátrica y neuropsicológica con posibles efectos a largo plazo, y se sospecha que en los próximos años podría haber un aumento de las tasas de incidencia de trastornos neurodegenerativos a nivel mundial.

El objetivo de este artículo es revisar la información más actualizada sobre el daño cerebral asociado al COVID-19 y su sintomatología neuropsiquiátrica. Los mecanismos exactos del daño cerebral aún no se han esclarecido, y se requiere continuar con investigaciones longitudinales e internacionales —inclusive estudios que incluyan variables epidemiológicas, clínicas y diagnósticas— para definirlos y establecer su implicación en la salud mental, así como sus consecuencias a largo plazo.

Durante a pandemia de COVID-19 foram relatados efeitos diretos e indiretos na saúde mental, incluindo sintomas neurológicos, neuropsiquiátricos e neuropsicológicos com possíveis efeitos no longo prazo, e suspeita-se que nos próximos anos poderá haver um aumento nas taxas de incidência de doenças neurodegenerativas em todo o mundo.O objetivo deste artigo é revisar as informações mais atualizadas sobre os danos cerebrais associados à COVID-19 e seus sintomas neuropsiquiátricos. Os mecanismos exatos desses danos ainda não foram esclarecidos, sendo necessário continuar com pesquisas longitudinais e internacionais – incluindo estudos que contenham variáveis – epidemiológicas, clínicas e diagnósticas – para defini-los e estabelecer sua repercussão na saúde mental, bem como suas consequências no longo prazo.

Keywords: COVID-19; Cerebrum; SARS-CoV-2; neurologic manifestations.

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