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Abstract

We used nanopore sequencing and phylogenetic analyses to identify a cosmopolitan genotype of dengue virus serotype 2 that was isolated from a 56-year-old male patient from the state of Goiás in Brazil. The emergence of a cosmopolitan genotype in Brazil will require risk assessment and surveillance to reduce epidemic potential.

Keywords: Brazil; South America; cosmopolitan genotype; dengue; dengue virus; genomic monitoring; vector-borne infections; viruses; zoonoses.

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Figures

Figure
Figure
Maximum-likelihood phylogenetic analysis for DENV-2 cosmopolitan genotype, Brazil. A) Midpoint rooted tree shows the evolutionary relationships of the complete genome sequence from the DENV-2 cosmopolitan genotype identified from a patient in Goiás state, Brazil (orange circle), and 1,089 publicly available sequences from GenBank. Scale bar indicates nucleotide substitutions per site. Colors represent different sampling locations. Blue highlighting shows area enlarged in panel B. B) Time-resolved maximum-likelihood tree showing the blue highlighted area from the larger tree in panel A. Colors indicate geographic location of sampling. Support for branching structure is shown by bootstrap values at key nodes. DENV-2, dengue virus serotype 2.
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