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. 2022 Sep;45(9):1465-1476.
doi: 10.1007/s00449-022-02756-2. Epub 2022 Jul 25.

High-sodium maltobionate production by immobilized Zymomonas mobilis cells in polyurethane

Roberta Cristina de Souza  1 , Leonardo Meirelles da Silva  1 , Sabrina Carra  2 , Maicon Flores  2 , Bruna Maria Puton  1 , Eloane Malvessi  2 , Eunice Valduga  1 , Jamile Zeni  3
Affiliations

High-sodium maltobionate production by immobilized Zymomonas mobilis cells in polyurethane

Roberta Cristina de Souza et al. Bioprocess Biosyst Eng. 2022 Sep.

Abstract

The purpose of this study was the production of maltobionic acid, in the form of sodium maltobionate, by Z. mobilis cells immobilized in polyurethane. The in situ immobilized system (0.125-0.35 mm) was composed of 7 g polyol, 3.5 g isocyanate, 0.02 g silicone, and 7 g Z. mobilis cell, at the concentration of 210 g/L. The bioconversion of maltose to sodium maltobionate was performed with different cell concentrations (7.0-9.0 gimobilized/Lreaction_medium), temperature (30.54-47.46 °C), pH (5.55-7.25), and substrate concentration (0.7-1.3 mol/L). The stability of the immobilized system was evaluated for 24 h bioconversion cycles and storage of 6 months. The maximum concentration of sodium maltobionate was 648.61 mmol/L in 34.34 h process (8.5 gdry_cell/Lreaction_medium) at 39 °C and pH 6.30. The immobilized system showed stability for 19 successive operational cycles of 24 h bioconversion and 6 months of storage, at 4 °C or 22 °C.

Keywords: Maltobionic acid; Operational stability; Storage; Z. mobilis in situ immobilized.

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