Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 25;204(8):520.
doi: 10.1007/s00203-022-03142-y.

Antibacterial effect of the combination of terpenoids

Takayoshi Yamaguchi  1
Affiliations

Antibacterial effect of the combination of terpenoids

Takayoshi Yamaguchi. Arch Microbiol. .

Abstract

Terpenoids are natural compounds originating from five-carbon isoprene units. Over 60,000 terpenoid structures have been identified, and they contribute to the flavor, color, growth, and development of plants. There are several reports on various physiological activities of terpenoids, such as antioxidative and anticancer activities. This study revealed that combinations of terpenoids have activities against a spectrum of bacteria. The combination of carvacrol and thymol has bacteriostatic and bactericidal activities. Four terpenoids (carvacrol, thymol, eugenol, and nootkatone) exhibited bacteriostatic and bactericidal activities when used at low concentrations for 5‒10 min. The most effective bactericidal activity was observed for gram-negative bacteria. A very weak bactericidal activity was observed against Staphylococcus aureus and Enterococcus faecalis. This study revealed the antibacterial potential of different combinations of terpenoids against several bacteria that were tested. Thus, new candidates for the development of antibacterial medicines are reported here for the effective treatment of infectious bacterial diseases.

Keywords: Bactericidal action; Bacteriostatic activity; Combination; Terpenoid.

PubMed Disclaimer

References

    1. Adukwu EC, Bowles M, Edwards-Jones V, Bone H (2016) Antimicrobial activity, cytotoxicity and chemical analysis of lemongrass essential oil (Cymbopogon flexuosus) and pure citral. Appl Microbiol Biotechnol 100:9619–9627. https://doi.org/10.1007/s00253-016-7807-y - DOI - PubMed - PMC
    1. Ansari MA, Fatima Z, Hameed S (2016) Anticandidal effect and mechanisms of monoterpenoid, perillyl alcohol against Candida albicans. PLoS ONE 11:e0162465. https://doi.org/10.1371/journal.pone.0162465 - DOI - PubMed - PMC
    1. Ashrafudoulla M, Mizan MFR, Ha AJ, Park SH, Ha SD (2020) Antibacterial and antibiofilm mechanism of eugenol against antibiotic resistance Vibrio parahaemolyticus. Food Microbiol 91:103500. https://doi.org/10.1016/j.fm.2020.103500 - DOI - PubMed
    1. Bartley GE, Scolnik PA (1995) Plant carotenoids: pigments for photoprotection, visual attraction, and human health. Plant Cell 7:1027–1038. https://doi.org/10.1105/tpc.7.7.1027 - DOI - PubMed - PMC
    1. Chen TC, Fonseca CO, Schönthal AH (2015) Preclinical development and clinical use of perillyl alcohol for chemoprevention and cancer therapy. Am J Cancer Res 5:1580–1593 - PubMed - PMC

MeSH terms

LinkOut - more resources