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Case Reports
. 2022 Jun 29;29(7):4587-4592.
doi: 10.3390/curroncol29070363.

Concurrent Waldenstrom's Macroglobulinemia and Myelodysplastic Syndrome with a Sequent t(10;13)(p13;q22) Translocation

Peter A DeRosa  1 , Kyle C Roche  2 , Victor E Nava  3   4 , Sunita Singh  5 , Min-Ling Liu  3   4 , Anita Agarwal  6   7
Affiliations
Case Reports

Concurrent Waldenstrom's Macroglobulinemia and Myelodysplastic Syndrome with a Sequent t(10;13)(p13;q22) Translocation

Peter A DeRosa et al. Curr Oncol. .

Abstract

Myelodysplastic syndromes (MDS) and Waldenstrom's macroglobulinemia (WM) are rarely synchronous. Ineffective myelopoiesis/hematopoiesis with clonal unilineage or multilineage dysplasia and cytopenias characterize MDS. Despite a myeloid origin, MDS can sometimes lead to decreased production, abnormal apoptosis or dysmaturation of B cells, and the development of lymphoma. WM includes bone marrow involvement by lymphoplasmacytic lymphoma (LPL) secreting monoclonal immunoglobulin M (IgM) with somatic mutation (L265P) of myeloid differentiation primary response 88 gene (MYD88) in 80-90%, or various mutations of C-terminal domain of the C-X-C chemokine receptor type 4 (CXCR4) gene in 20-40% of cases. A unique, progressive case of concurrent MDS and WM with several somatic mutations (some unreported before) and a novel balanced reciprocal translocation between chromosomes 10 and 13 is presented below.

Keywords: cytogenetics; genetics; hematology/oncology; lymphoma; myelodysplastic syndrome; pathology.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Initial diagnostic bone marrow biopsy and aspirate. The marrow is markedly hypercellular with diffuse lymphoid infiltrates consisting of predominant small lymphocytes, plasmacytic lymphocytes and rare plasma cells (H&E at 20× and 400×, respectively, in (A) and (B)). In the background, there is maturing trilineage hematopoiesis with dysmegakaryopoiesis and few blasts ((C). H and E at 1000×) and erythroid hyperplasia with dysplasia ((D) Wright-Giemsa stained aspirate at 1000×). (Scale bars = 2 mm in magnification at 20×, 50 μm at 400×, and 25 μm at magnification 1000×).
Figure 2
Figure 2
Immunohistochemistry of the initial bone marrow biopsy showing the lymphoplasmacytic lymphoma to be positive for Pax5 (A) and negative for CD5 (B) with a plasmacytic component negative for kappa (C) and positive for lambda (D). (Scale bars = 50 μm at magnification 400×).
Figure 3
Figure 3
Treatment timeline during patient’s clinical course.
See this image and copyright information in PMC

References

    1. Tefferi A., Vardiman J.W. Myelodysplastic syndromes. N. Engl. J. Med. 2009;361:1872–1885. doi: 10.1056/NEJMra0902908. - DOI - PubMed
    1. Teras L.R., De Santis C.E., Cerhan J.R., Morton L.M., Jemal A., Flowers C.R. 2016 US lymphoid malignancy statistics by World Health Organization subtypes. CA Cancer J. Clin. 2016;66:443–459. doi: 10.3322/caac.21357. - DOI - PubMed
    1. Owen R.G., Treon S.P., Al-Katib A., Fonseca R., Greipp P.R., McMaster M.L. Clinicopathological definition of Waldenstrom’s macroglobulinemia: Consensus panel recommendations from the Second International Workshop on Waldenstrom’s Macroglobulinemia. Semin. Oncol. 2003;30:110–115. doi: 10.1053/sonc.2003.50082. - DOI - PubMed
    1. Blann M.M., Velagaleti G.V., Morgan D.L., Martinez R.E., Conlin P.A., Tonk V.S. Interstitial deletion of 20q in a patient with Waldenstrom macroglobulinemia following chemotherapy. Cancer Genet Cytogenet. 2002;132:145–148. doi: 10.1016/S0165-4608(01)00538-6. - DOI - PubMed
    1. Liu Y.C., Miyazawa K., Sashida G., Kodama A., Ohyashiki K. Deletion (20q) as the sole abnormality in Waldenstrom macroglobulinemia suggests distinct pathogenesis of 20q11 anomaly. Cancer Genet Cytogenet. 2006;169:69–72. doi: 10.1016/j.cancergencyto.2006.03.013. - DOI - PubMed

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