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. 2022 Jul 12;29(7):4914-4922.
doi: 10.3390/curroncol29070390.

Surgery for Pituitary Tumor Apoplexy Is Associated with Rapid Headache and Cranial Nerve Improvement

Kevin A Cross  1 , Rupen Desai  1 , Ananth Vellimana  1   2 , Yupeng Liu  1 , Keith Rich  1   2 , Gregory Zipfel  1   2 , Ralph Dacey  1 , Michael Chicoine  1   2 , Cristine Klatt-Cromwell  3 , Jonathan McJunkin  3 , Patrik Pipkorn  3 , John S Schneider  3 , Julie Silverstein  4 , Albert H Kim  1   2
Affiliations

Surgery for Pituitary Tumor Apoplexy Is Associated with Rapid Headache and Cranial Nerve Improvement

Kevin A Cross et al. Curr Oncol. .

Abstract

Pituitary tumor apoplexy (PTA) classically comprises sudden-onset headache, loss of vision, ophthalmoparesis, and decreased consciousness. It typically results from hemorrhage and/or infarction within a pituitary adenoma. Presentation is heterologous, and optimal management is debated. The time course of recovery of cranial nerve deficits (CNDs) and headaches is not well established. In this study, a retrospective series of consecutive patients with PTA managed at a single academic institution over a 22-year period is presented. Headaches at the time of surgery were more severe in the early and subacute surgical cohort and improved significantly within 72 h postoperatively (p < 0.01). At one year, 90% of CNDs affecting cranial nerves (CNs) 3, 4, and 6 had recovered, with no differences between early (<4 d), subacute (4−14 d), and delayed (>14 d) time-to-surgery cohorts. Remarkably, half recovered within three days. In total, 56% of CN2 deficits recovered, with the early surgery cohort including more severe deficits and recovering at a lower rate (p = 0.01). No correlation of time-to-surgery and rapidity of recovery of CNDs was observed (p = 0.65, 0.72). Surgery for PTA is associated with rapid recovery of CNDs in the early, subacute, and delayed time frames, and with rapid headache improvement in the early and subacute time frames in 50% or more of patients.

Keywords: headache; ophthalmoplegia; pituitary apoplexy; pituitary tumor apoplexy; recovery.

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Conflict of interest statement

A.H.K. is a consultant for Monteris Medical and has received research grants from Monteris Medical, Stryker, and Collagen Matrix, the latter two regarding clinical outcomes studies for a dural substitute, which has no direct relation to this study. J.M. is a primary investigator for clinical studies with Chiasma, Corcept, and StrongBridge, none of which have direct relation to this study. C.K.-C. is a consultant for Medtronic and Intersect ENT, which have no direct relation to this study. M.C. received funding from (1) IMRIS Inc. for an unrestricted educational grant to support an iMRI database and brain tumor outcomes analysis project, the IMRIS Multicenter intraoperative MRI Neurosurgery Database (I-MiND), (2) The Head for the Cure Foundation, and (3) Mrs. Carol Rossfeld and The Alex & Alice Aboussie Family Charitable Foundation. I-MiND is Supported by Clinical and Translational Science Award (CTSA) Grant [UL1 TR000448] and The Siteman Comprehensive Cancer Center and NCI Cancer Center Support Grant P30 CA091842. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Pre- and Postoperative Headaches. Distributions of severity of headaches pre- and postoperatively in early (A), subacute (B), and delayed (C) cohorts. Individual subjects’ headache scores pre- and postoperatively in early (D), subacute (E), and delayed (F) cohorts. Distributions of headache severity by cohort in preoperative (G) and postoperative (H) time periods.
Figure 2
Figure 2
Postoperative Resolution and Improvement of Cranial Nerve Deficits. (A)—Postoperative Improvement and Resolution of CNDs. (B)—Resolution of CN2 vs CNs 3, 4, and 6. (C)—Resolution of CN2 by time-to-surgery cohort. (D)—Resolution of CNs 3, 4, and 6 by time-to-surgery cohort. (E)—Improvement in CN2 by time-to-surgery cohort. (F)—Improvement in CNs 3, 4, and 6 by time-to-surgery cohort.
Figure 3
Figure 3
Correlation of Time to Surgery and Rapidity of Postoperative Recovery. Linear regression analysis and F-Test as performed to assess correlation in (A)—CNs 3, 4, and 6, and (B)—CN2.
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