Insights into the Uses of Traditional Plants for Diabetes Nephropathy: A Review

doi:10.3390/cimb44070199

Review

. 2022 Jun 29;44(7):2887-2902.

doi: 10.3390/cimb44070199.

Insights into the Uses of Traditional Plants for Diabetes Nephropathy: A Review

Affiliations

¹ Department of Pharmacology, Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to be University) Mangaluru, Karnataka 575018, India.
² Department of Pharmacognosy, Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to be University) Mangaluru, Karnataka 575018, India.
³ Department of Pharmacy, King Salman Specialist Hospital, Hail 55436, Saudi Arabia.
⁴ Department of Pharmaceutical Care, Rafha Central Hospital, North Zone, Rafha 76312, Saudi Arabia.
⁵ Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia.
⁶ Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh 13713, Saudi Arabia.
⁷ Department of Anaesthesia Technology, College of Applied Sciences, AlMaarefa University, Dariyah, Riyadh 13713, Saudi Arabia.
⁸ Department of Emergency Medicine, Prince Sultan Military Medical City, Riyadh 12233, Saudi Arabia.
⁹ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia.
¹⁰ Pharmacy Department, Dr.Sulaiman Al-Habib Medical Group, Riyadh 11372, Saudi Arabia.

PMID: 35877423
PMCID: PMC9316237
DOI: 10.3390/cimb44070199

Review

Insights into the Uses of Traditional Plants for Diabetes Nephropathy: A Review

Haleema Shahin D H et al. Curr Issues Mol Biol. 2022.

. 2022 Jun 29;44(7):2887-2902.

doi: 10.3390/cimb44070199.

Authors

Affiliations

¹ Department of Pharmacology, Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to be University) Mangaluru, Karnataka 575018, India.
² Department of Pharmacognosy, Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to be University) Mangaluru, Karnataka 575018, India.
³ Department of Pharmacy, King Salman Specialist Hospital, Hail 55436, Saudi Arabia.
⁴ Department of Pharmaceutical Care, Rafha Central Hospital, North Zone, Rafha 76312, Saudi Arabia.
⁵ Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia.
⁶ Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh 13713, Saudi Arabia.
⁷ Department of Anaesthesia Technology, College of Applied Sciences, AlMaarefa University, Dariyah, Riyadh 13713, Saudi Arabia.
⁸ Department of Emergency Medicine, Prince Sultan Military Medical City, Riyadh 12233, Saudi Arabia.
⁹ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia.
¹⁰ Pharmacy Department, Dr.Sulaiman Al-Habib Medical Group, Riyadh 11372, Saudi Arabia.

PMID: 35877423
PMCID: PMC9316237
DOI: 10.3390/cimb44070199

Abstract

Diabetic nephropathy (DN) is a serious kidney illness characterized by proteinuria, glomerular enlargement, reduced glomerular filtration, and renal fibrosis. DN is the most common cause of end-stage kidney disease, accounting for nearly one-third of all cases of diabetes worldwide. Hyperglycemia is a major factor in the onset and progression of diabetic nephropathy. Many contemporary medicines are derived from plants since they have therapeutic properties and are relatively free of adverse effects. Glycosides, alkaloids, terpenoids, and flavonoids are among the few chemical compounds found in plants that are utilized to treat diabetic nephropathy. The purpose of this review was to consolidate information on the clinical and pharmacological evidence supporting the use of a variety of medicinal plants to treat diabetic nephropathy.

Keywords: antioxidant; diabetic nephropathy; medicinal plants; streptozotocin.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

**Figure 1**
Pathophysiology of diabetes nephropathy. Abbreviations: Advanced glycosylated end products (AGEs), glomerular basement membrane (GBM), protein kinase C (PKC), transforming growth factor beta(TGF-β).

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References

1. Sun H., Saeedi P., Karuranga S., Pinkepank M., Ogurtsova K., Duncan B.B., Stein C., Basit A., Chan J.C., Mbanya J.C., et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res. Clin. Pract. 2022;183:109–119. doi: 10.1016/j.diabres.2021.109119. - DOI - PMC - PubMed
1. Zhang S., Ge Q., Chen L., Chen K. Studies of the Anti-Diabetic Mechanism of Puerarialobata Based on Metabolomics and Network Pharmacology. Processes. 2021;9:1245. doi: 10.3390/pr9071245. - DOI
1. Magee C., Grieve D.J., Watson C.J., Brazil D.P. Diabetic nephropathy: A tangled web tounweave. Cardiovasc. Drugs Ther. 2017;31:579–592. doi: 10.1007/s10557-017-6755-9. - DOI - PMC - PubMed
1. Schena F.P., Gesualdo L. Pathogenetic mechanisms of diabetic nephropathy. J. Am. Soc. Nephrol. 2005;16:S30–S33. doi: 10.1681/ASN.2004110970. - DOI - PubMed
1. Vinod P.B. Pathophysiology of diabetic nephropathy. Clin. Queries Nephrol. 2012;1:121–126. doi: 10.1016/S2211-9477(12)70005-5. - DOI

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[1] Sun H., Saeedi P., Karuranga S., Pinkepank M., Ogurtsova K., Duncan B.B., Stein C., Basit A., Chan J.C., Mbanya J.C., et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res. Clin. Pract. 2022;183:109–119. doi: 10.1016/j.diabres.2021.109119. - DOI - PMC - PubMed

[2] Sun H., Saeedi P., Karuranga S., Pinkepank M., Ogurtsova K., Duncan B.B., Stein C., Basit A., Chan J.C., Mbanya J.C., et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res. Clin. Pract. 2022;183:109–119. doi: 10.1016/j.diabres.2021.109119. - DOI - PMC - PubMed

[3] Zhang S., Ge Q., Chen L., Chen K. Studies of the Anti-Diabetic Mechanism of Puerarialobata Based on Metabolomics and Network Pharmacology. Processes. 2021;9:1245. doi: 10.3390/pr9071245. - DOI

[4] Zhang S., Ge Q., Chen L., Chen K. Studies of the Anti-Diabetic Mechanism of Puerarialobata Based on Metabolomics and Network Pharmacology. Processes. 2021;9:1245. doi: 10.3390/pr9071245. - DOI

[5] Magee C., Grieve D.J., Watson C.J., Brazil D.P. Diabetic nephropathy: A tangled web tounweave. Cardiovasc. Drugs Ther. 2017;31:579–592. doi: 10.1007/s10557-017-6755-9. - DOI - PMC - PubMed

[6] Magee C., Grieve D.J., Watson C.J., Brazil D.P. Diabetic nephropathy: A tangled web tounweave. Cardiovasc. Drugs Ther. 2017;31:579–592. doi: 10.1007/s10557-017-6755-9. - DOI - PMC - PubMed

[7] Schena F.P., Gesualdo L. Pathogenetic mechanisms of diabetic nephropathy. J. Am. Soc. Nephrol. 2005;16:S30–S33. doi: 10.1681/ASN.2004110970. - DOI - PubMed

[8] Schena F.P., Gesualdo L. Pathogenetic mechanisms of diabetic nephropathy. J. Am. Soc. Nephrol. 2005;16:S30–S33. doi: 10.1681/ASN.2004110970. - DOI - PubMed

[9] Vinod P.B. Pathophysiology of diabetic nephropathy. Clin. Queries Nephrol. 2012;1:121–126. doi: 10.1016/S2211-9477(12)70005-5. - DOI

[10] Vinod P.B. Pathophysiology of diabetic nephropathy. Clin. Queries Nephrol. 2012;1:121–126. doi: 10.1016/S2211-9477(12)70005-5. - DOI

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Insights into the Uses of Traditional Plants for Diabetes Nephropathy: A Review

Affiliations

Insights into the Uses of Traditional Plants for Diabetes Nephropathy: A Review

Authors

Affiliations

Abstract

Conflict of interest statement

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References

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Abstract

Conflict of interest statement

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