Recent Discoveries on Marine Organism Immunomodulatory Activities

Abstract

Marine organisms have been shown to be a valuable source for biologically active compounds for the prevention and treatment of cancer, inflammation, immune system diseases, and other pathologies. The advantage of studying organisms collected in the marine environment lies in their great biodiversity and in the variety of chemical structures of marine natural products. Various studies have focused on marine organism compounds with potential pharmaceutical applications, for instance, as immunomodulators, to treat cancer and immune-mediated diseases. Modulation of the immune system is defined as any change in the immune response that can result in the induction, expression, amplification, or inhibition of any phase of the immune response. Studies very often focus on the effects of marine-derived compounds on macrophages, as well as lymphocytes, by analyzing the release of mediators (cytokines) by using the immunological assay enzyme-linked immunosorbent assay (ELISA), Western blot, immunofluorescence, and real-time PCR. The main sources are fungi, bacteria, microalgae, macroalgae, sponges, mollusks, corals, and fishes. This review is focused on the marine-derived molecules discovered in the last three years as potential immunomodulatory drugs.

Keywords: cancer; immunomodulatory activity; inflammation; marine drugs; marine organisms.

Figure 1

Immunomodulatory effects of marine-derived compounds. TNFα stands for tumor necrosis factor alpha, IL-1 for interleukin-1, IL-6 for interleukin-6, and NO for nitric oxide.

Figure 2

The figure shows the compounds which target the immune system approved by the Food and Drug Administration (FDA) for marketing (https://www.midwestern.edu/departments/marinepharmacology/clinical-pipeline; accessed on 5 May 2022).